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Development of a small molecule that corrects misfolding and increases secretion of Z α<sub>1</sub>‐antitrypsin

Development of a small molecule that corrects misfolding and increases secretion of Z α₁‐antitrypsin

David A Lomas, James A Irving, Christopher Arico‐Muendel, Svetlana Belyanskaya, Andrew Brewster, Murray Brown, Chun‐wa Chung, Hitesh Dave, Alexis Denis, Nerina Dodic, Anthony Dossang, Peter Eddershaw, Diana Klimaszewska, Imran Haq, Duncan S Holmes, Jonathan P Hutchinson, Alistair M Jagger, Toral Jakhria, Emilie Jigorel, John Liddle, Ken Lind, Stefan J Marciniak, Jeff Messer, Margaret Neu, Allison Olszewski, Adriana Ordonez, Riccardo Ronzoni, James Rowedder, Martin Rüdiger, Steve Skinner, Kathrine J Smith, Rebecca Terry, Lionel Trottet, Iain Uings, Steve Wilson, Zhengrong Zhu, Andrew C Pearce

Publication Date: 2021-01-29T00:00

Article Pages: 1

Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a <i>Shank2</i> mouse model for autism

Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism

Stefanie Grabrucker, Jessica Pagano, Johanna Schweizer, Carolina Urrutia‐Ruiz, Michael Schön, Kevin Thome, Günter Ehret, Andreas M Grabrucker, Rong Zhang, Bastian Hengerer, Jürgen Bockmann, Chiara Verpelli, Carlo Sala, Tobias M Boeckers

Publication Date: 2021-01-25T00:00

Article Pages: 1

Urinary proteome profiling for stratifying patients with familial Parkinson’s disease

Sebastian Virreira Winter, Ozge Karayel, Maximilian T Strauss, Shalini Padmanabhan, Matthew Surface, Kalpana Merchant, Roy N Alcalay, Matthias Mann

Publication Date: 2021-01-22T00:00

Article Pages: 1

Therapeutic development of group B <i>Streptococcus</i> meningitis by targeting a host cell signaling network involving EGFR

Therapeutic development of group B Streptococcus meningitis by targeting a host cell signaling network involving EGFR

Ningyu Zhu, Chengxian Zhang, Atish Prakash, Zheng Hou, Wei Liu, Weifeng She, Andrew Morris, Kwang Sik Kim

Publication Date: 2021-01-21T00:00

Article Pages: 1

Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper‐IgM syndrome

Valentina Vavassori, Elisabetta Mercuri, Genni E Marcovecchio, Maria C Castiello, Giulia Schiroli, Luisa Albano, Carrie Margulies, Frank Buquicchio, Elena Fontana, Stefano Beretta, Ivan Merelli, Andrea Cappelleri, Paola MV Rancoita, Vassilios Lougaris, Alessandro Plebani, Maria Kanariou, Arjan Lankester, Francesca Ferrua, Eugenio Scanziani, Cecilia Cotta‐Ramusino, Anna Villa, Luigi Naldini, Pietro Genovese

Publication Date: 2021-01-21T00:00

Article Pages: 1

Vegan diet in young children remodels metabolism and challenges the statuses of essential nutrients

Topi Hovinen, Liisa Korkalo, Riitta Freese, Essi Skaffari, Pirjo Isohanni, Mikko Niemi, Jaakko Nevalainen, Helena Gylling, Nicola Zamboni, Maijaliisa Erkkola, Anu Suomalainen

Publication Date: 2021-01-20T00:00

Article Pages: 1

Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF

Satoshi Yamanaka, Hidetaka Murai, Daisuke Saito, Gembu Abe, Etsuko Tokunaga, Takahiro Iwasaki, Hirotaka Takahashi, Hiroyuki Takeda, Takayuki Suzuki, Norio Shibata, Koji Tamura, Tatsuya Sawasaki

Publication Date: 2021-01-20T00:00

Article Pages: 1

Epigenetic gene expression links heart failure to memory impairment

Md Rezaul Islam, Dawid Lbik, M Sadman Sakib, Raoul Maximilian Hofmann, Tea Berulava, Martí Jiménez Mausbach, Julia Cha, Maria Goldberg, Elerdashvili Vakhtang, Christian Schiffmann, Anke Zieseniss, Dörthe Magdalena Katschinski, Farahnaz Sananbenesi, Karl Toischer, Andre Fischer

Publication Date: 2021-01-20T00:00

Article Pages: 1

PIF1 helicase promotes break‐induced replication in mammalian cells

Shibo Li, Hailong Wang, Sanaa Jehi, Jun Li, Shuo Liu, Zi Wang, Lan Truong, Takuya Chiba, Zefeng Wang, Xiaohua Wu

Publication Date: 2021-01-20T00:00

Article Pages: 1

Deletions in <i>CWH43</i> cause idiopathic normal pressure hydrocephalus

Deletions in CWH43 cause idiopathic normal pressure hydrocephalus

Hong Wei Yang, Semin Lee, Dejun Yang, Huijun Dai, Yan Zhang, Lei Han, Sijun Zhao, Shuo Zhang, Yan Ma, Marciana F Johnson, Anna K Rattray, Tatyana A Johnson, George Wang, Shaokuan Zheng, Rona S Carroll, Peter J Park, Mark D Johnson

Publication Date: 2021-01-18T00:00

Article Pages: 1

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