Proceedings of the National Academy of Sciences of the United States of America

Volume

Issue

Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer’s disease

Jodie Lord, Bradley Jermy, Rebecca Green, Andrew Wong, Jin Xu, Cristina Legido-Quigley, Richard Dobson, Marcus Richards, Petroula Proitsi

Publication Date: 2021-04-16T00:00

Research Article Pages: 1

Regulation of longevity by depolarization-induced activation of PLC-β–IP<sub>3</sub>R signaling in neurons

Regulation of longevity by depolarization-induced activation of PLC-β–IP₃R signaling in neurons

Ching-On Wong, Nicholas E. Karagas, Jewon Jung, Qiaochu Wang, Morgan A. Rousseau, Yufang Chao, Ryan Insolera, Pushpanjali Soppina, Catherine A. Collins, Yong Zhou, John F. Hancock, Michael X. Zhu, Kartik Venkatachalam

Publication Date: 2021-04-15T00:00

Research Article Pages: 1

Collagen IV differentially regulates planarian stem cell potency and lineage progression

Andy Chan, Sophia Ma, Bret J. Pearson, Danny Chan

Publication Date: 2021-04-15T00:00

Research Article Pages: 1

Predicting social tipping and norm change in controlled experiments

James Andreoni, Nikos Nikiforakis, Simon Siegenthaler

Publication Date: 2021-04-15T00:00

Research Article Pages: 1

Coexistence of three liquid phases in individual atmospheric aerosol particles

Yuanzhou Huang, Fabian Mahrt, Shaun Xu, Manabu Shiraiwa, Andreas Zuend, Allan K. Bertram

Publication Date: 2021-04-15T00:00

Research Article Pages: 1

Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma

Pinkal D. Patel, Yen-Lin Chen, Ramesh B. Kasetti, Prabhavathi Maddineni, William Mayhew, J. Cameron Millar, Dorette Z. Ellis, Swapnil K. Sonkusare, Gulab S. Zode

Publication Date: 2021-04-14T00:00

Research Article Pages: 1

The impact of identity by descent on fitness and disease in dogs

Jazlyn A. Mooney, Abigail Yohannes, Kirk E. Lohmueller

Publication Date: 2021-04-14T00:00

Research Article Pages: 1

Cryo-EM structure of <i>Mycobacterium smegmatis</i> DyP-loaded encapsulin

Cryo-EM structure of Mycobacterium smegmatis DyP-loaded encapsulin

Yanting Tang, An Mu, Yuying Zhang, Shan Zhou, Weiwei Wang, Yuezheng Lai, Xiaoting Zhou, Fengjiang Liu, Xiuna Yang, Hongri Gong, Quan Wang, Zihe Rao

Publication Date: 2021-04-14T00:00

Research Article Pages: 1

Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing

So-Jin Park-Holohan, Elisabetta Brunello, Thomas Kampourakis, Martin Rees, Malcolm Irving, Luca Fusi

Publication Date: 2021-04-13T00:00

Research Article Pages: 1

A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis

Alireza Ghanbarpour, Diana P. Valverde, Thomas J. Melia, Karin M. Reinisch

Publication Date: 2021-04-13T00:00

Brief Report Pages: 1

Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma

Najla Kfoury, Zongtai Qi, Briana C. Prager, Michael N. Wilkinson, Lauren Broestl, Kristopher C. Berrett, Arnav Moudgil, Sumithra Sankararaman, Xuhua Chen, Jason Gertz, Jeremy N. Rich, Robi D. Mitra, Joshua B. Rubin

Publication Date: 2021-04-13T00:00

Research Article Pages: 1

Repeated mutation of a developmental enhancer contributed to human thermoregulatory evolution

Daniel Aldea, Yuji Atsuta, Blerina Kokalari, Stephen F. Schaffner, Rexxi D. Prasasya, Adam Aharoni, Heather L. Dingwall, Bailey Warder, Yana G. Kamberov

Publication Date: 2021-04-13T00:00

Research Article Pages: 1