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Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
Benjamin Caballero, Mathieu Bourdenx, Enrique Luengo, Antonio Diaz, Peter Dongmin Sohn, Xu Chen, Chao Wang, Yves R. Juste, Susanne Wegmann, Bindi Patel, Zapporah T. Young, Szu Yu Kuo, Jose Antonio Rodriguez-Navarro, Hao Shao, Manuela G. Lopez, Celeste M. Karch, Alison M. Goate, Jason E. Gestwicki, Bradley T. Hyman, Li Gan, Ana Maria Cuervo
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Article Pages: 1 Open access contents
GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice
Wei Yuan, Liaoxun Lu, Muding Rao, Yang Huang, Chun-e Liu, Shuang Liu, Yue Zhao, Huicong Liu, Jiangli Zhu, Tianzhu Chao, Can Wu, Junyan Ren, Luxian Lv, Wenqiang Li, Shiqian Qi, Yinming Liang, Shijing Yue, Jian Gao, Zhongjian Zhang, Eryan Kong
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Article Pages: 1 Open access contents
Neurofilament light chain as a potential biomarker for monitoring neurodegeneration in X-linked adrenoleukodystrophy
Isabelle Weinhofer, Paulus Rommer, Bettina Zierfuss, Patrick Altmann, Martha Foiani, Amanda Heslegrave, Henrik Zetterberg, Andreas Gleiss, Patricia L. Musolino, Yi Gong, Sonja Forss-Petter, Thomas Berger, Florian Eichler, Patrick Aubourg, Wolfgang Köhler, Johannes Berger
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Article Pages: 1 Open access contents
Parkinson's disease: Alterations in iron and redox biology as a key to unlock therapeutic strategies
L. Ma, M. Gholam Azad, M. Dharmasivam, V. Richardson, R.J. Quinn, Y. Feng, D.L. Pountney, K.F. Tonissen, G.D. Mellick, I. Yanatori, D.R. Richardson
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Article Pages: 1 Open access contents
SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
Alyssa E. Johnson, Brian O. Orr, Richard D. Fetter, Armen J. Moughamian, Logan A. Primeaux, Ethan G. Geier, Jennifer S. Yokoyama, Bruce L. Miller, Graeme W. Davis
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Article Pages: 1 Open access contents
Engineering of a bona fide light-operated calcium channel
Lian He, Liuqing Wang, Hongxiang Zeng, Peng Tan, Guolin Ma, Sisi Zheng, Yaxin Li, Lin Sun, Fei Dou, Stefan Siwko, Yun Huang, Youjun Wang, Yubin Zhou
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Article Pages: 1 Open access contents
Small molecule targeting r(UGGAA)<sub><i>n</i></sub> disrupts RNA foci and alleviates disease phenotype in <i>Drosophila</i> model
Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
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Article Pages: 1 Open access contents
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
Peng Wang, Yihong Ye
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Article Pages: 1 Open access contents
Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration
Veronica H Ryan, Theodora M Perdikari, Mandar T Naik, Camillo F Saueressig, Jeremy Lins, Gregory L Dignon, Jeetain Mittal, Anne C Hart, Nicolas L Fawzi
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Article Pages: 1 Open access contents
Targeting MCL1 to induce mitophagy is a potential therapeutic strategy for Alzheimer disease
Xufeng Cen, Xiaoyan Xu, Hongguang Xia
Article Pages: 1 Open access contents