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Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor
Zizheng Zou, Xiyuan Hu, Tiao Luo, Zhengnan Ming, Xiaodan Chen, Li Xia, Wensong Luo, Jijia Li, Na Xu, Ling Chen, Dongsheng Cao, Min Wen, Fanrong Kong, Kunjian Peng, Yuanzhu Xie, Xuan Li, Dayou Ma, Chuanyu Yang, Ceshi Chen, Wenjun Yi, Ousheng Liu, Suyou Liu, Junli Luo, Zhiyong Luo
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Article Pages: 1 Open access contents
Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase
Edward Kalkreuter, Kyle S. Bingham, Aaron M. Keeler, Andrew N. Lowell, Jennifer J. Schmidt, David H. Sherman, Gavin J. Williams
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Article Pages: 1 Open access contents
Marine furanocembranoids-inspired macrocycles enabled by Pd-catalyzed unactivated C(sp<sup>3</sup>)-H olefination mediated by donor/donor carbenes
Jiping Hao, Xueying Guo, Shijun He, Zhongliang Xu, Lu Chen, Zhongyu Li, Bichao Song, Jianping Zuo, Zhenyang Lin, Weibo Yang
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Article Pages: 1 Open access contents
Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate‐Directed Formation of Quinolones versus Quinazolinones
Manuel Einsiedler, Cooper S. Jamieson, Mark A. Maskeri, Kendall N. Houk, Tobias A. M. Gulder
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Article Pages: 5 Open access contents
Structural basis for the biosynthesis of lovastatin
Jialiang Wang, Jingdan Liang, Lu Chen, Wei Zhang, Liangliang Kong, Chao Peng, Chen Su, Yi Tang, Zixin Deng, Zhijun Wang
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Article Pages: 1 Open access contents
Lipopeptide-mediated bacterial interaction enables cooperative predator defense
Shuaibing Zhang, Ruchira Mukherji, Somak Chowdhury, Lisa Reimer, Pierre Stallforth
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Article Pages: 1 Open access contents
The Landscape of Recombination Events That Create Nonribosomal Peptide Diversity
Martin Baunach, Somak Chowdhury, Pierre Stallforth, Elke Dittmann
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Article Pages: 14 Open access contents
Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359
Cornelia Hermes, René Richarz, Daniel A. Wirtz, Julian Patt, Wiebke Hanke, Stefan Kehraus, Jan Hendrik Voß, Jim Küppers, Tsubasa Ohbayashi, Vigneshwaran Namasivayam, Judith Alenfelder, Asuka Inoue, Peter Mergaert, Michael Gütschow, Christa E. Müller, Evi Kostenis, Gabriele M. König, Max Crüsemann
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Article Pages: 1 Open access contents
An Unexpected Split‐Merge Pathway in the Assembly of the Symmetric Nonribosomal Peptide Antibiotic Closthioamide
Kyle L. Dunbar, Maria Dell, Evelyn M. Molloy, Hannah Büttner, Jana Kumpfmüller, Christian Hertweck
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Article Pages: 5 Open access contents
Total Synthesis of the Diterpene Waihoensene
Lisa‐Catherine Rosenbaum, Maximilian Häfner, Tanja Gaich
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Article Pages: 3 Open access contents