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Regulation of longevity by depolarization-induced activation of PLC-β–IP<sub>3</sub>R signaling in neurons
Ching-On Wong, Nicholas E. Karagas, Jewon Jung, Qiaochu Wang, Morgan A. Rousseau, Yufang Chao, Ryan Insolera, Pushpanjali Soppina, Catherine A. Collins, Yong Zhou, John F. Hancock, Michael X. Zhu, Kartik Venkatachalam
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Article Pages: 1 Open access contents
Signatures of immune dysfunction in HIV and HCV infection share features with chronic inflammation in aging and persist after viral reduction or elimination
Cesar J. Lopez Angel, Edward A. Pham, Huixun Du, Francesco Vallania, Benjamin J. Fram, Kevin Perez, Thai Nguyen, Yael Rosenberg-Hasson, Aijaz Ahmed, Cornelia L. Dekker, Philip M. Grant, Purvesh Khatri, Holden T. Maecker, Jeffrey S. Glenn, Mark M. Davis, David Furman
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Article Pages: 1 Open access contents
LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss
Fei Liu, Yujia Yuan, Lin Bai, Longhui Yuan, Lan Li, Jingping Liu, Younan Chen, Yanrong Lu, Jingqiu Cheng, Jie Zhang
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Article Pages: 1 Open access contents
Methionine restriction alleviates age-associated cognitive decline via fibroblast growth factor 21
Bo Ren, Luanfeng Wang, Lin Shi, Xin Jin, Yan Liu, Rui Hai Liu, Fei Yin, Enrique Cadenas, Xiaoshuang Dai, Zhigang Liu, Xuebo Liu
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Article Pages: 1 Open access contents
Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system
Ekin Bolukbasi, Nathaniel S. Woodling, Dobril K. Ivanov, Jennifer Adcott, Andrea Foley, Arjunan Rajasingam, Lauren M. Gittings, Benjamin Aleyakpo, Teresa Niccoli, Janet M. Thornton, Linda Partridge
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Article Pages: 1 Open access contents
Childhood self-control forecasts the pace of midlife aging and preparedness for old age
Leah S. Richmond-Rakerd, Avshalom Caspi, Antony Ambler, Tracy d’Arbeloff, Marieke de Bruine, Maxwell Elliott, HonaLee Harrington, Sean Hogan, Renate M. Houts, David Ireland, Ross Keenan, Annchen R. Knodt, Tracy R. Melzer, Sena Park, Richie Poulton, Sandhya Ramrakha, Line Jee Hartmann Rasmussen, Elizabeth Sack, Adam T. Schmidt, Maria L. Sison, Jasmin Wertz, Ahmad R. Hariri, Terrie E. Moffitt
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Article Pages: 1 Open access contents
Macrophage LC3-associated phagocytosis is an immune defense against <i>Streptococcus pneumoniae</i> that diminishes with host aging
Megumi Inomata, Shuying Xu, Pallavi Chandra, Simin N. Meydani, Genzou Takemura, Jennifer A. Philips, John M. Leong
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Article Pages: 8 Open access contents
Universal features of annealing and aging in compaction of granular piles
Paula A. Gago, Stefan Boettcher
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Article Pages: 4 Open access contents
Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance
Juneyoung Lee, Venugopal R. Venna, David J. Durgan, Huanan Shi, Jacob Hudobenko, Nagireddy Putluri, Joseph Petrosino, Louise D. McCullough, Robert M. Bryan
Article Pages: 1 Open access contents
Elevated gut microbiome abundance of <i>Christensenellaceae, Porphyromonadaceae and Rikenellaceae</i> is associated with reduced visceral adipose tissue and healthier metabolic profile in Italian elderly
Teresa Tavella, Simone Rampelli, Giulia Guidarelli, Alberto Bazzocchi, Chiara Gasperini, Estelle Pujos-Guillot, Blandine Comte, Monica Barone, Elena Biagi, Marco Candela, Claudio Nicoletti, Fawzi Kadi, Giuseppe Battista, Stefano Salvioli, Paul W. O’Toole, Claudio Franceschi, Patrizia Brigidi, Silvia Turroni, Aurelia Santoro
Article Pages: 1 Open access contents