Nova Reader - Subject

Climate change and the emergence of fungal pathogens

2021-04-29T00:00

RhoGTPases and inflammasomes: Guardians of effector-triggered immunity

2021-04-29T00:00

Pathogens have evolved smart strategies to invade hosts and hijack their immune responses. One such strategy is the targeting of the host RhoGTPases by toxins or virulence factors to hijack the cytoskeleton dynamic and immune processes. In response to this microbial attack, the host has evolved an elegant strategy to monitor the function of virulence factors and toxins by sensing the abnormal activity of RhoGTPases. This innate immune strategy of sensing bacterial effector targeting RhoGTPase appears to be a bona fide example of effector-triggered immunity (ETI). Here, we review recently discovered mechanisms by which the host can sense the activity of these toxins through NOD and NOD-like receptors (NLRs).

Fungal cell wall: An underexploited target for antifungal therapies

2021-04-22T00:00

Toward understanding microbiota homeostasis in the plant kingdom

2021-04-22T00:00

A diverse community of microorganisms inhabits various parts of a plant. Recent findings indicate that perturbations to the normal microbiota can be associated with positive and negative effects on plant health. In this review, we discuss these findings in the context of understanding how microbiota homeostasis is regulated in plants for promoting health and/or for preventing dysbiosis.

The role of antimicrobial peptides in the evolution of endosymbiotic protein import

2021-04-15T00:00

C. elegans as a new tractable host to study infections by animal pathogenic oomycetes

2021-03-04T00:00

Ferroptosis and microbial pathogenesis

2021-03-04T00:00

Five key aspects of metaproteomics as a tool to understand functional interactions in host-associated microbiomes

2021-02-25T00:00

G protein-coupled receptors: The choreographers of innate immunity in Caenorhabditis elegans

2021-01-21T00:00

Short and sweet: How glycans impact prion conversion, cofactor interactions, and cross-species transmission

2021-01-14T00:00

Mechanisms and therapeutic potential of collateral sensitivity to antibiotics

2021-01-14T00:00

DUSP11 and triphosphate RNA balance during virus infection

2021-01-14T00:00

Exploring amino acid and peptide transporters as therapeutic targets to attenuate virulence and antibiotic resistance in Staphylococcus aureus

2021-01-14T00:00

Quorum sensing across bacterial and viral domains

2021-01-07T00:00

Joining forces: Leveraging novel combination therapies to combat infections with eukaryotic pathogens

2020-12-31T00:00