Nova Reader - Subject https://www.novareader.co Default RSS Feed en-us Newgen KnowledgeWorks <![CDATA[High levels of circulating osteopontin in inflammatory lung disease regardless of Sars‐CoV‐2 infection]]> https://www.novareader.co/book/isbn/10.15252/emmm.202114124 This study independently confirms increased levels of osteopontin in COVID‐19 patients but also suggests that osteopontin cannot be used as a biomarker of SARS‐CoV‐2 infection, as elevated levels of circulating osteopontin are found in inflammatory lung disease regardless of SARS‐CoV‐2 infection.

]]> <![CDATA[High levels of circulating osteopontin in inflammatory lung disease regardless of Sars‐CoV‐2 infection]]> https://www.novareader.co/book/isbn/10.15252/emmm.202114124 This study independently confirms increased levels of osteopontin in COVID‐19 patients but also suggests that osteopontin cannot be used as a biomarker of SARS‐CoV‐2 infection, as elevated levels of circulating osteopontin are found in inflammatory lung disease regardless of SARS‐CoV‐2 infection.

]]> <![CDATA[Potential and pitfalls of whole transcriptome-based immunogenetic marker identification in acute lymphoblastic leukemia; a EuroMRD and EuroClonality-NGS Working Group study]]> https://www.novareader.co/book/isbn/10.1038/s41375-021-01154-z <![CDATA[Colourfulness as a possible measure of object proximity in the larval zebrafish brain]]> https://www.novareader.co/book/isbn/10.1016/j.cub.2021.01.030 The encoding of light increments and decrements by separate On- and Off- systems is a fundamental ingredient of vision, which supports edge detection and makes efficient use of the limited dynamic range of visual neurons1. Theory predicts that the neural representation of On- and Off-signals should be balanced, including across an animal’s visible spectrum. Here we find that larval zebrafish violate this textbook expectation: in the zebrafish brain, UV-stimulation near exclusively gives On-responses, blue/green stimulation mostly Off-responses, and red-light alone elicits approximately balanced On- and Off-responses (see also references2, 3, 4). We link these findings to zebrafish visual ecology, and suggest that the observed spectral tuning boosts the encoding of object ‘colourfulness’, which correlates with object proximity in their underwater world5.

Bartel et al. probe the bulk spectral tuning of the larval zebrafish visual brain using mesoscale two-photon imaging. They find a strong wavelength dependence of response polarity: UV-responses are nearly exclusively On, green/blue responses are mostly Off, and only red responses show an approximate balance of On and Off.

]]> <![CDATA[Ruxolitinib withdrawal due to the COVID-19]]> https://www.novareader.co/book/isbn/10.1038/s41375-021-01214-4 <![CDATA[Dynamic follow‐up of smoldering multiple myeloma identifies a subset of patients at high risk of progression]]> https://www.novareader.co/book/isbn/10.1002/ajh.26062 <![CDATA[A DKMS (German Bone Marrow Donor Center) view on cryopreservation of unrelated donor stem cell products during the Covid‐19 pandemic]]> https://www.novareader.co/book/isbn/10.1002/ajh.26081 <![CDATA[A phase I clinical trial of avelumab in combination with decitabine as first line treatment of unfit patients with acute myeloid leukemia]]> https://www.novareader.co/book/isbn/10.1002/ajh.26043 <![CDATA[Response to: Ruxolitinib withdrawal due to the COVID-19]]> https://www.novareader.co/book/isbn/10.1038/s41375-021-01187-4 <![CDATA[Mechanisms for substance use disorders in COVID-19]]> https://www.novareader.co/book/isbn/10.1038/s41380-021-01041-0