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        <title>Nova Reader - Subject</title>
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        <copyright>Newgen KnowledgeWorks</copyright>
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            <title><![CDATA[Dynamic prioritization of COVID-19 vaccines when social distancing is limited for essential workers]]></title>
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            <link>https://www.novareader.co/book/isbn/10.1073/pnas.2025786118</link>
            <description><![CDATA[<p class="para" id="N65542">Vaccines are a key intervention to reduce the burden of the COVID-19 pandemic. However, vaccine supply and administration capacity will initially be limited. Due to these constraints, it is critical to understand how vaccine deployment can be targeted to minimize the overall burden of disease. In this paper, we solve for optimal dynamic strategies to allocate a limited supply of vaccines over a population differentiated by age and essential worker status that minimizes the number of total deaths, years of life lost, or infections. We find that older essential workers are typically targeted first. However, depending on the objective and alternative model scenarios considered, younger essential workers may be prioritized to control spread or seniors to directly control mortality.</p><p class="para" id="N65539">COVID-19 vaccines have been authorized in multiple countries, and more are under rapid development. Careful design of a vaccine prioritization strategy across sociodemographic groups is a crucial public policy challenge given that 1) vaccine supply will be constrained for the first several months of the vaccination campaign, 2) there are stark differences in transmission and severity of impacts from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) across groups, and 3) SARS-CoV-2 differs markedly from previous pandemic viruses. We assess the optimal allocation of a limited vaccine supply in the United States across groups differentiated by age and essential worker status, which constrains opportunities for social distancing. We model transmission dynamics using a compartmental model parameterized to capture current understanding of the epidemiological characteristics of COVID-19, including key sources of group heterogeneity (susceptibility, severity, and contact rates). We investigate three alternative policy objectives (minimizing infections, years of life lost, or deaths) and model a dynamic strategy that evolves with the population epidemiological status. We find that this temporal flexibility contributes substantially to public health goals. Older essential workers are typically targeted first. However, depending on the objective, younger essential workers are prioritized to control spread or seniors to directly control mortality. When the objective is minimizing deaths, relative to an untargeted approach, prioritization averts deaths on a range between 20,000 (when nonpharmaceutical interventions are strong) and 300,000 (when these interventions are weak). We illustrate how optimal prioritization is sensitive to several factors, most notably, vaccine effectiveness and supply, rate of transmission, and the magnitude of initial infections.</p>]]></description>
            <pubDate><![CDATA[2021-04-02T00:00]]></pubDate>
        </item><item>
            <title><![CDATA[Earnings growth and the wealth distribution]]></title>
            <media:thumbnail url="https://storage.googleapis.com/nova-demo-unsecured-files/unsecured/content-1766060224627-14235530-a2b7-4a40-b80d-69604846c7a7/cover.png"></media:thumbnail>
            <link>https://www.novareader.co/book/isbn/10.1073/pnas.2025368118</link>
            <description><![CDATA[<p class="para" id="N65542">Forces that shape wealth inequality are intermediated through an individual’s nonfinancial earnings growth rate g<div class="imageVideo"><img src="" alt=""/></div> and an equilibrium interest rate r<div class="imageVideo"><img src="" alt=""/></div>. Individuals’ earnings growth rate and survival probability interact with their preferences about consumption plans to determine aggregate savings and the interest rate and make wealth more unequally distributed and have a fatter tail than labor earnings, as in US data.</p><p class="para" id="N65539">As measured by Gini coefficients, fractile inequalities, and tail power laws, wealth is distributed less equally across people than are labor earnings. We study how luck, attitudes that shape saving decisions, and growth rates of labor earnings balance each other in ways that simultaneously shape joint distributions across people of labor earnings, age, and wealth together with an equilibrium rate of return on savings that plays a pivotal role in balancing contending forces. Strong motives for people to save and for firms to demand capital raise an equilibrium interest rate enough to make wealth grow faster than labor earnings. That makes cross-sectional wealth more unevenly distributed and have a fatter tail than labor earnings, as in US data.</p>]]></description>
            <pubDate><![CDATA[2021-04-07T00:00]]></pubDate>
        </item><item>
            <title><![CDATA[Confidence intervals for policy evaluation in adaptive experiments]]></title>
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            <link>https://www.novareader.co/book/isbn/10.1073/pnas.2014602118</link>
            <description><![CDATA[<p class="para" id="N65542">Randomized controlled trials are central to the scientific process, but they can be costly. For example, a clinical trial may assign patients to treatments that are detrimental to them. Adaptive experimental designs, such as multiarmed bandit algorithms, reduce costs by increasing the probability of assigning promising treatments over the course of the experiment. However, because observations collected by these methods are dependent and their distribution is nonstationary, statistical inference can be challenging. We propose a treatment-effect estimator that has an asymptotically unbiased and normal test statistic under straightforward, relatively weak conditions on the adaptive design. This estimator generalizes for a variety of parameters of interest.</p><p class="para" id="N65539">Adaptive experimental designs can dramatically improve efficiency in randomized trials. But with adaptively collected data, common estimators based on sample means and inverse propensity-weighted means can be biased or heavy-tailed. This poses statistical challenges, in particular when the experimenter would like to test hypotheses about parameters that were not targeted by the data-collection mechanism. In this paper, we present a class of test statistics that can handle these challenges. Our approach is to adaptively reweight the terms of an augmented inverse propensity-weighting estimator to control the contribution of each term to the estimator’s variance. This scheme reduces overall variance and yields an asymptotically normal test statistic. We validate the accuracy of the resulting estimates and their CIs in numerical experiments and show that our methods compare favorably to existing alternatives in terms of mean squared error, coverage, and CI size.</p>]]></description>
            <pubDate><![CDATA[2021-04-05T00:00]]></pubDate>
        </item><item>
            <title><![CDATA[Twenty-year economic impacts of deworming]]></title>
            <media:thumbnail url="https://storage.googleapis.com/nova-demo-unsecured-files/unsecured/content-1766030569786-7f4164b0-47c0-4504-a497-99e47548f3ec/cover.png"></media:thumbnail>
            <link>https://www.novareader.co/book/isbn/10.1073/pnas.2023185118</link>
            <description><![CDATA[<p class="para" id="N65542">The belief that investing in child health and nutrition can generate improvements in individuals’ future quality of life is the rationale for many policy initiatives around the world. Yet there remains limited evidence on the causal impacts of child health gains on adult living standards, especially in developing countries. This study contributes evidence that addresses leading methodological concerns, by using variation in child health via a randomized health intervention that provided deworming treatment to Kenyan children. We estimate impacts on individual living standards up to 20 y later among a representative sample of participants, and find those in the deworming treatment group experience meaningful gains in adult living standards and earnings, and shifts in sectors of residence and employment.</p><p class="para" id="N65539">Estimating the impact of child health investments on adult living standards entails multiple methodological challenges, including the lack of experimental variation in health status, an inability to track individuals over time, and accurately measuring living standards and productivity in low-income settings. This study exploits a randomized school health intervention that provided deworming treatment to Kenyan children, and uses longitudinal data to estimate impacts on economic outcomes up to 20 y later. The effective respondent tracking rate was 84%. Individuals who received two to three additional years of childhood deworming experienced a 14% gain in consumption expenditures and 13% increase in hourly earnings. There are also shifts in sectors of residence and employment: treatment group individuals are 9% more likely to live in urban areas, and experience a 9% increase in nonagricultural work hours. Most effects are concentrated among males and older individuals. The observed consumption and earnings benefits, together with deworming’s low cost when distributed at scale, imply that a conservative estimate of its annualized social internal rate of return is 37%, a high return by any standard.</p>]]></description>
            <pubDate><![CDATA[2021-03-31T00:00]]></pubDate>
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            <title><![CDATA[Least-cost targets and avoided fossil fuel capacity in India’s pursuit of renewable energy]]></title>
            <media:thumbnail url="https://storage.googleapis.com/nova-demo-unsecured-files/unsecured/content-1766004674119-0dbbbee5-d41b-4011-8f17-5b81aafa81ea/cover.png"></media:thumbnail>
            <link>https://www.novareader.co/book/isbn/10.1073/pnas.2008128118</link>
            <description><![CDATA[<p class="para" id="N65542">This study examines electricity and carbon mitigation costs associated with achieving aggressive renewable energy targets in India’s electricity grid in 2030. We find that wind-majority or balanced wind–solar targets have the lowest carbon mitigation costs, which invites revisiting India’s proposed solar-majority targets. Contrary to prevailing assumptions, achieving high renewable energy targets will not avert the need to build new fossil fuel power plants. However, building significant numbers of wind and solar plants (600 GW) will reduce how often fossil fuel power plants must run, holding India’s 2030 electricity emissions at its 2018 level at costs comparable to a fossil fuel-dominated grid. As costs decrease, battery storage can cost-effectively avert the need for new fossil fuel power plants.</p><p class="para" id="N65539">India has set aggressive targets to install more than 400 GW of wind and solar electricity generation by 2030, with more than two-thirds of that capacity coming from solar. This paper examines the electricity and carbon mitigation costs to reliably operate India’s grid in 2030 for a variety of wind and solar targets (200 GW to 600 GW) and the most promising options for reducing these costs. We find that systems where solar photovoltaic comprises only 25 to 50% of the total renewable target have the lowest carbon mitigation costs in most scenarios. This result invites a reexamination of India’s proposed solar-majority targets. We also find that, compared to other regions and contrary to prevailing assumptions, meeting high renewable targets will avoid building very few new fossil fuel (coal and natural gas) power plants because of India’s specific weather patterns and need to meet peak electricity demand. However, building 600 GW of renewable capacity, with the majority being wind plants, reduces how often fossil fuel power plants run, and this amount of capacity can hold India’s 2030 emissions below 2018 levels for less than the social cost of carbon. With likely wind and solar cost declines and increases in coal energy costs, balanced or wind-majority high renewable energy systems (600 GW or ≈<div class="imageVideo"><img src="" alt=""/></div> 45% share by energy) could result in electricity costs similar to a fossil fuel-dominated system. As an alternative strategy for meeting peak electricity demand, battery storage can avert the need for new fossil fuel capacity but is cost effective only at low capital costs (≈<div class="imageVideo"><img src="" alt=""/></div> USD 150 per kWh).</p>]]></description>
            <pubDate><![CDATA[2021-03-22T00:00]]></pubDate>
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            <title><![CDATA[The effects of school closures on SARS-CoV-2 among parents and teachers]]></title>
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            <link>https://www.novareader.co/book/isbn/10.1073/pnas.2020834118</link>
            <description><![CDATA[<p class="para" id="N65542">Many countries closed schools during the pandemic to contain the spread of SARS-CoV-2. Sweden closed upper-secondary schools, while lower-secondary schools remained open, allowing for an evaluation of school closures. This study analyzes the impact of school closures on the spread of SARS-CoV-2 by comparing groups exposed and not exposed to open schools. We find that exposure to open schools resulted in a small increase in infections among parents. Among teachers, the infection rate doubled, and infections spilled over to their partners. This suggests that keeping lower-secondary schools open had a minor impact on the overall spread of SARS-CoV-2 in society. However, teachers are affected, and measures to protect them could be considered.</p><p class="para" id="N65539">To reduce the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), most countries closed schools, despite uncertainty if school closures are an effective containment measure. At the onset of the pandemic, Swedish upper-secondary schools moved to online instruction, while lower-secondary schools remained open. This allows for a comparison of parents and teachers differently exposed to open and closed schools, but otherwise facing similar conditions. Leveraging rich Swedish register data, we connect all students and teachers in Sweden to their families and study the impact of moving to online instruction on the incidence of SARS-CoV-2 and COVID-19. We find that, among parents, exposure to open rather than closed schools resulted in a small increase in PCR-confirmed infections (odds ratio [OR] 1.17; 95% CI [CI95] 1.03 to 1.32). Among lower-secondary teachers, the infection rate doubled relative to upper-secondary teachers (OR 2.01; CI95 1.52 to 2.67). This spilled over to the partners of lower-secondary teachers, who had a higher infection rate than their upper-secondary counterparts (OR 1.29; CI95 1.00 to 1.67). When analyzing COVID-19 diagnoses from healthcare visits and the incidence of severe health outcomes, results are similar for teachers, but weaker for parents and teachers’ partners. The results for parents indicate that keeping lower-secondary schools open had minor consequences for the overall transmission of SARS-CoV-2 in society. The results for teachers suggest that measures to protect teachers could be considered.</p>]]></description>
            <pubDate><![CDATA[2021-02-11T00:00]]></pubDate>
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            <title><![CDATA[Effects of short birth spacing on birth-order differences in child stunting: Evidence from India]]></title>
            <media:thumbnail url="https://storage.googleapis.com/nova-demo-unsecured-files/unsecured/content-1765980494663-83c83641-5dd5-459f-bf2e-1d0dfd4606f1/cover.png"></media:thumbnail>
            <link>https://www.novareader.co/book/isbn/10.1073/pnas.2017834118</link>
            <description><![CDATA[<p class="para" id="N65542">The question of whether firstborn children have a height advantage over later-born children is important, given the persistently poor height outcomes in developing countries. Using data on young Indian children, we show that later-born children lag behind firstborns in stunting outcomes. This is only true, though, if higher birth-order children were born within 3 y of the birth of their elder siblings. No difference in height-for-age is observed for children born with spacing of 3 or more years. India’s family planning interventions have largely focused on reducing the total fertility rate with less attention given to length of birth spacing between children. A stronger focus on increasing the time interval between births could prevent adverse stunting outcomes for surviving children.</p><p class="para" id="N65539">Do firstborn children have a height advantage? Empirical findings have found mostly that, yes, second or higher-order children often lag behind firstborns in height outcomes, especially in developing countries. However, empirical investigations of birth-order effects on child height overlook the potential impact that birth spacing can have. We provide an explanation for the negative birth-order effect on stunting outcomes for young Indian children and show it is driven by short preceding-birth spacing. We find that firstborn children are taller than children of higher birth order: The height-for-age gap for third (or higher)-order children is twice the gap for children second in birth order. However, this pattern is observed when spacing between later-born children and their immediate elder siblings is fewer than 3 y. Interestingly, the firstborn height advantage disappears when later-born children are born at least 3 y after their elder siblings. Thus, our findings indicate that spacing length between children explains differences in height, over birth order. Although India’s family planning policy has resulted in a substantial reduction in total fertility, its achievement in spacing subsequent births has been less impressive. In showing that spacing can alleviate or aggravate birth-order effects on attained height, our study fills an evidence gap: Reducing fertility alone may not be sufficient in overcoming negative birth-order effects. To reduce the detrimental effects of birth order on child stunting, policy responses—and therefore research priorities—require a stronger focus on increasing the time period between births.</p>]]></description>
            <pubDate><![CDATA[2021-02-18T00:00]]></pubDate>
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