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SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia
Juan C. García-Cañaveras, Olga Lancho, Gregory S. Ducker, Jonathan M. Ghergurovich, Xincheng Xu, Victoria da Silva-Diz, Sonia Minuzzo, Stefano Indraccolo, Hahn Kim, Daniel Herranz, Joshua D. Rabinowitz
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Article Pages: 11 Open access contents
Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation
Zhe Chen, Zong-Heng Wang, Guofeng Zhang, Christopher K.E. Bleck, Dillon J. Chung, Grey P. Madison, Eric Lindberg, Christian Combs, Robert S. Balaban, Hong Xu
Publication Date:
Article Pages: 1 Open access contents
RIM-binding protein couples synaptic vesicle recruitment to release sites
Astrid G. Petzoldt, Torsten W.B. Götz, Jan Heiner Driller, Janine Lützkendorf, Suneel Reddy-Alla, Tanja Matkovic-Rachid, Sunbin Liu, Elena Knoche, Sara Mertel, Vladimir Ugorets, Martin Lehmann, Niraja Ramesh, Christine Brigitte Beuschel, Benno Kuropka, Christian Freund, Ulrich Stelzl, Bernhard Loll, Fan Liu, Markus C. Wahl, Stephan J. Sigrist
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Article Pages: 1 Open access contents
A modified lysosomal organelle mediates nonlytic egress of reovirus
Isabel Fernández de Castro, Raquel Tenorio, Paula Ortega-González, Jonathan J. Knowlton, Paula F. Zamora, Christopher H. Lee, José J. Fernández, Terence S. Dermody, Cristina Risco
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Article Pages: 1 Open access contents
Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
Nurulain Ho, Wei Sheng Yap, Jiaming Xu, Haoxi Wu, Jhee Hong Koh, Wilson Wen Bin Goh, Bhawana George, Shu Chen Chong, Stefan Taubert, Guillaume Thibault
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Article Pages: 1 Open access contents
Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis
Vineet Choudhary, Ola El Atab, Giulia Mizzon, William A. Prinz, Roger Schneiter
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Article Pages: 1 Open access contents
Daratumumab induces mechanisms of immune activation through CD38+ NK cell targeting
Domenico Viola, Ada Dona, Enrico Caserta, Estelle Troadec, Francesca Besi, Tinisha McDonald, Lucy Ghoda, Emine Gulsen Gunes, James F Sanchez, Jihane Khalife, Marianna Martella, Chatchada Karanes, Myo Htut, Xiuli Wang, Michael Rosenzweig, Arnab Chowdhury, Douglas Sborov, Rodney R Miles, Paul J. Yazaki, Todd Ebner, Craig C. Hofmeister, Stephen J Forman, Steven T Rosen, Guido Marcucci, John Shively, Jonathan J Keats, Amrita Krishnan, Flavia Pichiorri
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Article Pages: 11 Open access contents
H3K79me2/3 controls enhancer–promoter interactions and activation of the pan-cancer stem cell marker <i>PROM1</i>/CD133 in MLL-AF4 leukemia cells
Laura Godfrey, Nicholas T. Crump, Sorcha O’Byrne, I-Jun Lau, Siobhan Rice, Joe R. Harman, Thomas Jackson, Natalina Elliott, Gemma Buck, Christopher Connor, Ross Thorne, David J. H. F. Knapp, Olaf Heidenreich, Paresh Vyas, Pablo Menendez, Sarah Inglott, Philip Ancliff, Huimin Geng, Irene Roberts, Anindita Roy, Thomas A. Milne
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Article Pages: 16 Open access contents
Immunomodulatory drugs activate NK cells <i>via</i> both Zap-70 and cereblon-dependent pathways
Teru Hideshima, Daisuke Ogiya, Jiye Liu, Takeshi Harada, Keiji Kurata, Jooeun Bae, Walter Massefski, Kenneth C Anderson
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Article Pages: 11 Open access contents
CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression
Kristen Fousek, Junji Watanabe, Sujith K. Joseph, Ann George, Xingyue An, Tiara T. Byrd, Jessica S. Morris, Annie Luong, Melisa A. Martínez-Paniagua, Khaled Sanber, Shoba A. Navai, Ahmed Z. Gad, Vita S. Salsman, Pretty R. Mathew, Hye Na Kim, Dimitrios L. Wagner, Lorenzo Brunetti, Albert Jang, Matthew L. Baker, Navin Varadarajan, Meenakshi Hegde, Yong-Mi Kim, Nora Heisterkamp, Hisham Abdel-Azim, Nabil Ahmed
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Article Pages: 14 Open access contents