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Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells
Josep Biayna, Isabel Garcia-Cao, Miguel M. Álvarez, Marina Salvadores, Jose Espinosa-Carrasco, Marcel McCullough, Fran Supek, Travis H. Stracker
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Article Pages: 1 Open access contents
Orchestrating privacy-protected big data analyses of data from different resources with R and DataSHIELD
Yannick Marcon, Tom Bishop, Demetris Avraam, Xavier Escriba-Montagut, Patricia Ryser-Welch, Stuart Wheater, Paul Burton, Juan R. González
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Article Pages: 1 Open access contents
Predicting antimicrobial mechanism-of-action from transcriptomes: A generalizable explainable artificial intelligence approach
Josh L. Espinoza, Chris L. Dupont, Aubrie O’Rourke, Sinem Beyhan, Pavel Morales, Amy Spoering, Kirsten J. Meyer, Agnes P. Chan, Yongwook Choi, William C. Nierman, Kim Lewis, Karen E. Nelson
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Article Pages: 1 Open access contents
Characterization of <i>C9orf72</i> haplotypes to evaluate the effects of normal and pathological variations on its expression and splicing
Israel Ben-Dor, Crystal Pacut, Yuval Nevo, Eva L. Feldman, Benjamin E. Reubinoff
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Article Pages: 1 Open access contents
Viral genomic, metagenomic and human transcriptomic characterization and prediction of the clinical forms of COVID-19
Christophe Rodriguez, Nicolas de Prost, Slim Fourati, Claudie Lamoureux, Guillaume Gricourt, Melissa N’debi, Florence Canoui-Poitrine, Isaac Désveaux, Oriane Picard, Vanessa Demontant, Elisabeth Trawinski, Raphaël Lepeule, Laure Surgers, William Vindrios, Jean-Daniel Lelièvre, Nicolas Mongardon, Olivier Langeron, José L. Cohen, Armand Mekontso-Dessap, Paul-Louis Woerther, Jean-Michel Pawlotsky
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Article Pages: 1 Open access contents
Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms
Gareth J. Staton, Simon R. Clegg, Stuart Ainsworth, Stuart Armstrong, Stuart D. Carter, Alan D. Radford, Alistair Darby, Jonathan Wastling, Neil Hall, Nicholas J. Evans
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Article Pages: 1 Open access contents
Drivers of linkage disequilibrium across a species’ geographic range
Kay Lucek, Yvonne Willi
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Article Pages: 1 Open access contents
IKAROS is required for the measured response of NOTCH target genes upon external NOTCH signaling
Maud Lemarié, Stefania Bottardi, Lionel Mavoungou, Helen Pak, Eric Milot
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Article Pages: 1 Open access contents
Searching for fat tails in CRISPR-Cas systems: Data analysis and mathematical modeling
Yekaterina S. Pavlova, David Paez-Espino, Andrew Yu. Morozov, Ilya S. Belalov
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Article Pages: 1 Open access contents
The capacity of origins to load MCM establishes replication timing patterns
Livio Dukaj, Nicholas Rhind
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Article Pages: 1 Open access contents