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Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase
Gloria Gamiz-Arco, Luis I. Gutierrez-Rus, Valeria A. Risso, Beatriz Ibarra-Molero, Yosuke Hoshino, Dušan Petrović, Jose Justicia, Juan Manuel Cuerva, Adrian Romero-Rivera, Burckhard Seelig, Jose A. Gavira, Shina C. L. Kamerlin, Eric A. Gaucher, Jose M. Sanchez-Ruiz
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Article Pages: 1 Open access contents
Two distinct catalytic pathways for GH43 xylanolytic enzymes unveiled by X-ray and QM/MM simulations
Mariana A. B. Morais, Joan Coines, Mariane N. Domingues, Renan A. S. Pirolla, Celisa C. C. Tonoli, Camila R. Santos, Jessica B. L. Correa, Fabio C. Gozzo, Carme Rovira, Mario T. Murakami
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Article Pages: 1 Open access contents
Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis
Lin Zhong, Xiaotong Diao, Na Zhang, Fengwei Li, Haibo Zhou, Hanna Chen, Xianping Bai, Xintong Ren, Youming Zhang, Dalei Wu, Xiaoying Bian
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Article Pages: 1 Open access contents
Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines
Manmohan Sharma, Nipun Malhotra, Manickam Yogavel, Karl Harlos, Bruno Melillo, Eamon Comer, Arthur Gonse, Suhel Parvez, Branko Mitasev, Francis G. Fang, Stuart L. Schreiber, Amit Sharma
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Article Pages: 1 Open access contents
Structural basis for the multi-activity factor Rad5 in replication stress tolerance
Miaomiao Shen, Nalini Dhingra, Quan Wang, Chen Cheng, Songbiao Zhu, Xiaolin Tian, Jun Yu, Xiaoxin Gong, Xuzhichao Li, Hongwei Zhang, Xin Xu, Liting Zhai, Min Xie, Ying Gao, Haiteng Deng, Yongning He, Hengyao Niu, Xiaolan Zhao, Song Xiang
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Article Pages: 1 Open access contents
Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds
Anja Kolarič, Thomas Germe, Martina Hrast, Clare E. M. Stevenson, David M. Lawson, Nicolas P. Burton, Judit Vörös, Anthony Maxwell, Nikola Minovski, Marko Anderluh
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Article Pages: 1 Open access contents
Inhibiting <i>Mycobacterium tuberculosis</i> CoaBC by targeting an allosteric site
Vitor Mendes, Simon R. Green, Joanna C. Evans, Jeannine Hess, Michal Blaszczyk, Christina Spry, Owain Bryant, James Cory-Wright, Daniel S-H. Chan, Pedro H. M. Torres, Zhe Wang, Navid Nahiyaan, Sandra O’Neill, Sebastian Damerow, John Post, Tracy Bayliss, Sasha L. Lynch, Anthony G. Coyne, Peter C. Ray, Chris Abell, Kyu Y. Rhee, Helena I. M. Boshoff, Clifton E. Barry, Valerie Mizrahi, Paul G. Wyatt, Tom L. Blundell
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Article Pages: 1 Open access contents
Insights into SusCD-mediated glycan import by a prominent gut symbiont
Declan A. Gray, Joshua B. R. White, Abraham O. Oluwole, Parthasarathi Rath, Amy J. Glenwright, Adam Mazur, Michael Zahn, Arnaud Baslé, Carl Morland, Sasha L. Evans, Alan Cartmell, Carol V. Robinson, Sebastian Hiller, Neil A. Ranson, David N. Bolam, Bert van den Berg
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Article Pages: 1 Open access contents
Structural basis for nuclear import selectivity of pioneer transcription factor SOX2
Bikshapathi Jagga, Megan Edwards, Miriam Pagin, Kylie M. Wagstaff, David Aragão, Noelia Roman, Jeffrey D. Nanson, Shane R. Raidal, Nicole Dominado, Murray Stewart, David A. Jans, Gary R. Hime, Silvia K. Nicolis, Christopher F. Basler, Jade K. Forwood
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Article Pages: 1 Open access contents
Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein
Thomas G. Flower, Cosmo Z. Buffalo, Richard M. Hooy, Marc Allaire, Xuefeng Ren, James H. Hurley
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Article Pages: 1 Open access contents