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Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization
Juan F. Bada Juarez, Peter J. Judge, Suliman Adam, Danny Axford, Javier Vinals, James Birch, Tristan O. C. Kwan, Kin Kuan Hoi, Hsin-Yung Yen, Anthony Vial, Pierre-Emmanuel Milhiet, Carol V. Robinson, Igor Schapiro, Isabel Moraes, Anthony Watts
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Article Pages: 1 Open access contents
Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction
Rongfeng Zhu, Gong Zhang, Miao Jing, Yu Han, Jiaofeng Li, Jingyi Zhao, Yulong Li, Peng R. Chen
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Article Pages: 1 Open access contents
Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF
David McMillan, Carlos Martinez-Fleites, John Porter, David Fox, Rachel Davis, Prashant Mori, Tom Ceska, Bruce Carrington, Alastair Lawson, Tim Bourne, James O’Connell
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Article Pages: 1 Open access contents
A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF
Daniel J. Lightwood, Rebecca J. Munro, John Porter, David McMillan, Bruce Carrington, Alison Turner, Anthony Scott-Tucker, Elizabeth S. Hickford, Antje Schmidt, David Fox, Alison Maloney, Tom Ceska, Tim Bourne, James O’Connell, Alastair D. G. Lawson
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Article Pages: 1 Open access contents
Unique structural solution from a <i>V</i><sub><i>H</i></sub><i>3-30</i> antibody targeting the hemagglutinin stem of influenza A viruses
Wayne D. Harshbarger, Derrick Deming, Gordon J. Lockbaum, Nattapol Attatippaholkun, Maliwan Kamkaew, Shurong Hou, Mohan Somasundaran, Jennifer P. Wang, Robert W. Finberg, Quan Karen Zhu, Celia A. Schiffer, Wayne A. Marasco
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Article Pages: 1 Open access contents
High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication
Jessica S. Williams, Percy P. Tumbale, Mercedes E. Arana, Julian A. Rana, R. Scott Williams, Thomas A. Kunkel
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Article Pages: 1 Open access contents
Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1
Jiqing Du, Marie-Kristin von Wrisberg, Burak Gulen, Matthias Stahl, Christian Pett, Christian Hedberg, Kathrin Lang, Sabine Schneider, Aymelt Itzen
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Article Pages: 1 Open access contents
Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism
Yufei Han, Qian Zhuang, Bo Sun, Wenping Lv, Sheng Wang, Qingjie Xiao, Bin Pang, Youli Zhou, Fuxing Wang, Pengliang Chi, Qisheng Wang, Zhen Li, Lizhe Zhu, Fuping Li, Dong Deng, Ying-Chih Chiang, Zhenfei Li, Ruobing Ren
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Article Pages: 1 Open access contents
Structure and assembly of the diiron cofactor in the heme-oxygenase–like domain of the <i>N</i>-nitrosourea–producing enzyme SznF
Molly J. McBride, Sarah R. Pope, Kai Hu, C. Denise Okafor, Emily P. Balskus, J. Martin Bollinger, Amie K. Boal
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Article Pages: 1 Open access contents
Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis
Martina K. Ried, Rebekka Wild, Jinsheng Zhu, Joka Pipercevic, Kristina Sturm, Larissa Broger, Robert K. Harmel, Luciano A. Abriata, Ludwig A. Hothorn, Dorothea Fiedler, Sebastian Hiller, Michael Hothorn
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Article Pages: 1 Open access contents