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IP<sub>6</sub>-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion

IP₆-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion

Hong Lin, Yuan Yan, Yifan Luo, Wing Yan So, Xiayun Wei, Xiaozhe Zhang, Xiaoli Yang, Jun Zhang, Yang Su, Xiuyan Yang, Bobo Zhang, Kangjun Zhang, Nan Jiang, Billy Kwok Chong Chow, Weiping Han, Fengchao Wang, Feng Rao

Publication Date: 2021-04-28T00:00

Article Pages: 1

Crystal structures of an E1–E2–ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification

Lingmin Yuan, Zongyang Lv, Melanie J. Adams, Shaun K. Olsen

Publication Date: 2021-04-22T00:00

Article Pages: 1

Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12

Omar M. Khan, Jorge Almagro, Jessica K. Nelson, Stuart Horswell, Vesela Encheva, Kripa S. Keyan, Bruce E. Clurman, Ambrosius P. Snijders, Axel Behrens

Publication Date: 2021-04-06T00:00

Article Pages: 1

VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism

Yu-Hsuan Chen, Tzu-Yu Huang, Yu-Tung Lin, Shu-Yu Lin, Wen-Hsin Li, Hsiang-Jung Hsiao, Ruei-Liang Yan, Hong-Wen Tang, Zhao-Qing Shen, Guang-Chao Chen, Kuen-Phon Wu, Ting-Fen Tsai, Ruey-Hwa Chen

Publication Date: 2021-02-26T00:00

Article Pages: 1

RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination

Leo Kiss, Dean Clift, Nadine Renner, David Neuhaus, Leo C. James

Publication Date: 2021-02-22T00:00

Article Pages: 1

Microthermal-induced subcellular-targeted protein damage in cells on plasmonic nanosilver-modified surfaces evokes a two-phase HSP-p97/VCP response

Martin Mistrik, Zdenek Skrott, Petr Muller, Ales Panacek, Lucie Hochvaldova, Katarina Chroma, Tereza Buchtova, Veronika Vandova, Libor Kvitek, Jiri Bartek

Publication Date: 2021-01-29T00:00

Article Pages: 1

<i>circNDUFB2</i> inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

Botai Li, Lili Zhu, Chunlai Lu, Cun Wang, Hui Wang, Haojie Jin, Xuhui Ma, Zhuoan Cheng, Chengtao Yu, Siying Wang, Qiaozhu Zuo, Yangyang Zhou, Jun Wang, Chen Yang, Yuanyuan Lv, Liyan Jiang, Wenxin Qin

Publication Date: 2021-01-12T00:00

Article Pages: 1

Structural basis for the multi-activity factor Rad5 in replication stress tolerance

Miaomiao Shen, Nalini Dhingra, Quan Wang, Chen Cheng, Songbiao Zhu, Xiaolin Tian, Jun Yu, Xiaoxin Gong, Xuzhichao Li, Hongwei Zhang, Xin Xu, Liting Zhai, Min Xie, Ying Gao, Haiteng Deng, Yongning He, Hengyao Niu, Xiaolan Zhao, Song Xiang

Publication Date: 2021-01-12T00:00

Article Pages: 1