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Cut-like homeobox 1 (<i>CUX1</i>) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia
Emmanuelle Supper, Saskia Rudat, Vivek Iyer, Alastair Droop, Kim Wong, Jean-François Spinella, Patrick Thomas, Guy Sauvageau, David J. Adams, Chi C. Wong
Publication Date: 30 April, 2021
Article Pages: 1 Open access contents
Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
Hudie Wei, Lingzhi Qu, Shuyan Dai, Yun Li, Haolan Wang, Yilu Feng, Xiaojuan Chen, Longying Jiang, Ming Guo, Jun Li, Zhuchu Chen, Lin Chen, Ye Zhang, Yongheng Chen
Publication Date: 16 April, 2021
Article Pages: 1 Open access contents
Dominant role of <i>CDKN2B/p15INK4B</i> of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis
Yong Xia, Yan Liu, Chao Yang, Diane M. Simeone, Tung-Tien Sun, David J. DeGraff, Moon-shong Tang, Yingkai Zhang, Xue-Ru Wu
Publication Date: 06 April, 2021
Article Pages: 1 Open access contents
EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction
Jing Zhao, Alan Blayney, Xiaorong Liu, Lauren Gandy, Weihua Jin, Lufeng Yan, Jeung-Hoi Ha, Ashley J. Canning, Michael Connelly, Chao Yang, Xinyue Liu, Yuanyuan Xiao, Michael S. Cosgrove, Sozanne R. Solmaz, Yingkai Zhang, David Ban, Jianhan Chen, Stewart N. Loh, Chunyu Wang
Publication Date: 12 February, 2021
Article Pages: 1 Open access contents
The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3
Catherine A. Vaughan, Shilpa Singh, Mark A. Subler, Jolene J. Windle, Kazushi Inoue, Elizabeth A. Fry, Raghavendra Pillappa, Steven R. Grossman, Brad Windle, W. Andrew Yeudall, Swati Palit Deb, Sumitra Deb
Publication Date: 29 January, 2021
Article Pages: 1 Open access contents
Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates
Marina Farkas, Hideharu Hashimoto, Yingtao Bi, Ramana V. Davuluri, Lois Resnick-Silverman, James J. Manfredi, Erik W. Debler, Steven B. McMahon
Publication Date: 20 January, 2021
Article Pages: 1 Open access contents
Structural insights into TSC complex assembly and GAP activity on Rheb
Huirong Yang, Zishuo Yu, Xizi Chen, Jiabei Li, Ningning Li, Jiaxuan Cheng, Ning Gao, Hai-Xin Yuan, Dan Ye, Kun-Liang Guan, Yanhui Xu
Publication Date: 12 January, 2021
Article Pages: 1 Open access contents
Ubiquitination in the regulation of inflammatory cell death and cancer
Peter E. Cockram, Matthias Kist, Sumit Prakash, Si-Han Chen, Ingrid E. Wertz, Domagoj Vucic
Publication Date: 11 January, 2021
Article Pages: 14 Open access contents
RUNX3 methylation drives hypoxia-induced cell proliferation and antiapoptosis in early tumorigenesis
Sun Hee Lee, Do Young Hyeon, Soo-Hyun Yoon, Ji-Hak Jeong, Saeng-Myung Han, Ju-Won Jang, Minh Phuong Nguyen, Xin-Zi Chi, Sojin An, Kyung-gi Hyun, Hee-Jung Jung, Ji-Joon Song, Suk-Chul Bae, Woo-Ho Kim, Daehee Hwang, You Mie Lee
Publication Date: 28 October, 2020
Article Pages: 18 Open access contents