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CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells
Mitchell G. Kluesner, Walker S. Lahr, Cara-lin Lonetree, Branden A. Smeester, Xiaohong Qiu, Nicholas J. Slipek, Patricia N. Claudio Vázquez, Samuel P. Pitzen, Emily J. Pomeroy, Madison J. Vignes, Samantha C. Lee, Samuel P. Bingea, Aneesha A. Andrew, Beau R. Webber, Branden S. Moriarity
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Article Pages: 1 Open access contents
Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation
Eleonore Maury, Benoit Navez, Sonia M. Brichard
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Article Pages: 1 Open access contents
Deletion of CTCF sites in the <i>SHH</i> locus alters enhancer–promoter interactions and leads to acheiropodia
Aki Ushiki, Yichi Zhang, Chenling Xiong, Jingjing Zhao, Ilias Georgakopoulos-Soares, Lauren Kane, Kirsty Jamieson, Michael J. Bamshad, Deborah A. Nickerson, Yin Shen, Laura A. Lettice, Elizabeth Lemos Silveira-Lucas, Florence Petit, Nadav Ahituv
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Article Pages: 1 Open access contents
Redundant and non-redundant cytokine-activated enhancers control <i>Csn1s2b</i> expression in the lactating mouse mammary gland
Hye Kyung Lee, Michaela Willi, Tyler Kuhns, Chengyu Liu, Lothar Hennighausen
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Article Pages: 1 Open access contents
Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states
Peter Chovanec, Amanda J. Collier, Christel Krueger, Csilla Várnai, Claudia I. Semprich, Stefan Schoenfelder, Anne E. Corcoran, Peter J. Rugg-Gunn
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Article Pages: 1 Open access contents
Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms
Thomas A. Johnson, Ville Paakinaho, Sohyoung Kim, Gordon L. Hager, Diego M. Presman
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Article Pages: 1 Open access contents
Structural basis of ribosomal RNA transcription regulation
Yeonoh Shin, M. Zuhaib Qayyum, Danil Pupov, Daria Esyunina, Andrey Kulbachinskiy, Katsuhiko S. Murakami
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Article Pages: 1 Open access contents
GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers
Yapeng Li, Junfeng Gao, Mohammad Kamran, Laura Harmacek, Thomas Danhorn, Sonia M. Leach, Brian P. O’Connor, James R. Hagman, Hua Huang
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Article Pages: 1 Open access contents
Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates
Marina Farkas, Hideharu Hashimoto, Yingtao Bi, Ramana V. Davuluri, Lois Resnick-Silverman, James J. Manfredi, Erik W. Debler, Steven B. McMahon
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Article Pages: 1 Open access contents
Dissection of the <i>Fgf8</i> regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy
A. Hörnblad, S. Bastide, K. Langenfeld, F. Langa, F. Spitz
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Article Pages: 1 Open access contents