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Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition
Federica Verginelli, Alberto Pisacane, Gennaro Gambardella, Antonio D’Ambrosio, Ermes Candiello, Marco Ferrio, Mara Panero, Laura Casorzo, Silvia Benvenuti, Eliano Cascardi, Rebecca Senetta, Elena Geuna, Andrea Ballabio, Filippo Montemurro, Anna Sapino, Paolo M. Comoglio, Carla Boccaccio
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Article Pages: 1 Open access contents
Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells
Chia-Lin Chen, Sheng-Chieh Hsu, Tan-Ya Chung, Cheng-Ying Chu, Hung-Jung Wang, Pei-Wen Hsiao, Shauh-Der Yeh, David K. Ann, Yun Yen, Hsing-Jien Kung
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Article Pages: 1 Open access contents
RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways
Victoria Gudiño, Sebastian Öther-Gee Pohl, Caroline V. Billard, Patrizia Cammareri, Alfonso Bolado, Stuart Aitken, David Stevenson, Adam E. Hall, Mark Agostino, John Cassidy, Colin Nixon, Alex von Kriegsheim, Paz Freile, Linda Popplewell, George Dickson, Laura Murphy, Ann Wheeler, Malcolm Dunlop, Farhat Din, Douglas Strathdee, Owen J. Sansom, Kevin B. Myant
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Article Pages: 1 Open access contents
SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
Xiaowen Wang, Hong Zhang, Russell Sapio, Jun Yang, Justin Wong, Xin Zhang, Jessie Y. Guo, Sharon Pine, Holly Van Remmen, Hong Li, Eileen White, Chen Liu, Megerditch Kiledjian, Dimitri G. Pestov, X. F. Steven Zheng
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Article Pages: 1 Open access contents
Gilteritinib overcomes lorlatinib resistance in <i>ALK</i>-rearranged cancer
Hayato Mizuta, Koutaroh Okada, Mitsugu Araki, Jun Adachi, Ai Takemoto, Justyna Kutkowska, Kohei Maruyama, Noriko Yanagitani, Tomoko Oh-hara, Kana Watanabe, Keiichi Tamai, Luc Friboulet, Kazuhiro Katayama, Biao Ma, Yoko Sasakura, Yukari Sagae, Mutsuko Kukimoto-Niino, Mikako Shirouzu, Satoshi Takagi, Siro Simizu, Makoto Nishio, Yasushi Okuno, Naoya Fujita, Ryohei Katayama
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Article Pages: 1 Open access contents
The tumor therapy landscape of synthetic lethality
Biyu Zhang, Chen Tang, Yanli Yao, Xiaohan Chen, Chi Zhou, Zhiting Wei, Feiyang Xing, Lan Chen, Xiang Cai, Zhiyuan Zhang, Shuyang Sun, Qi Liu
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Article Pages: 1 Open access contents
Chromosomally unstable tumor cells specifically require KIF18A for proliferation
Carolyn Marquis, Cindy L. Fonseca, Katelyn A. Queen, Lisa Wood, Sarah E. Vandal, Heidi L. H. Malaby, Joseph E. Clayton, Jason Stumpff
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Article Pages: 1 Open access contents
Mutant-selective degradation by BRAF-targeting PROTACs
Shanique Alabi, Saul Jaime-Figueroa, Zhan Yao, Yijun Gao, John Hines, Kusal T. G. Samarasinghe, Lea Vogt, Neal Rosen, Craig M. Crews
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Article Pages: 1 Open access contents
A hybrid semiconducting organosilica-based O<sub>2</sub> nanoeconomizer for on-demand synergistic photothermally boosted radiotherapy
Wei Tang, Zhen Yang, Liangcan He, Liming Deng, Parinaz Fathi, Shoujun Zhu, Ling Li, Bo Shen, Zhantong Wang, Orit Jacobson, Jibin Song, Jianhua Zou, Ping Hu, Min Wang, Jing Mu, Yaya Cheng, Yuanyuan Ma, Longguang Tang, Wenpei Fan, Xiaoyuan Chen
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Article Pages: 1 Open access contents
A modular and controllable T cell therapy platform for acute myeloid leukemia
Mohamed-Reda Benmebarek, Bruno L. Cadilha, Monika Herrmann, Stefanie Lesch, Saskia Schmitt, Stefan Stoiber, Abbass Darwich, Christian Augsberger, Bettina Brauchle, Lisa Rohrbacher, Arman Oner, Matthias Seifert, Melanie Schwerdtfeger, Adrian Gottschlich, Felicitas Rataj, Nadja C. Fenn, Christian Klein, Marion Subklewe, Stefan Endres, Karl-Peter Hopfner, Sebastian Kobold
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Article Pages: 14 Open access contents