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Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling
Wei Ting C. Lee, Yandong Yin, Michael J. Morten, Peter Tonzi, Pam Pam Gwo, Diana C. Odermatt, Mauro Modesti, Sharon B. Cantor, Kerstin Gari, Tony T. Huang, Eli Rothenberg
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Article Pages: 1 Open access contents
Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements
Janett Göhring, Florian Kellner, Lukas Schrangl, René Platzer, Enrico Klotzsch, Hannes Stockinger, Johannes B. Huppa, Gerhard J. Schütz
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Article Pages: 1 Open access contents
Super-resolved visualization of single DNA-based tension sensors in cell adhesion
Thomas Schlichthaerle, Caroline Lindner, Ralf Jungmann
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Article Pages: 1 Open access contents
Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
Nicholas A. Arce, Wenpeng Cao, Alexander K. Brown, Emily R. Legan, Moriah S. Wilson, Emma-Ruoqi Xu, Michael C. Berndt, Jonas Emsley, X. Frank Zhang, Renhao Li
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Article Pages: 1 Open access contents
Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase
Simon Bo Jensen, Sara Thodberg, Shaheena Parween, Matias E. Moses, Cecilie C. Hansen, Johannes Thomsen, Magnus B. Sletfjerding, Camilla Knudsen, Rita Del Giudice, Philip M. Lund, Patricia R. Castaño, Yanet G. Bustamante, Maria Natalia Rojas Velazquez, Flemming Steen Jørgensen, Amit V. Pandey, Tomas Laursen, Birger Lindberg Møller, Nikos S. Hatzakis
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Article Pages: 1 Open access contents
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
Jasmine Cubuk, Jhullian J. Alston, J. Jeremías Incicco, Sukrit Singh, Melissa D. Stuchell-Brereton, Michael D. Ward, Maxwell I. Zimmerman, Neha Vithani, Daniel Griffith, Jason A. Wagoner, Gregory R. Bowman, Kathleen B. Hall, Andrea Soranno, Alex S. Holehouse
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Article Pages: 1 Open access contents
DNA replication origins retain mobile licensing proteins
Humberto Sánchez, Kaley McCluskey, Theo van Laar, Edo van Veen, Filip M. Asscher, Belén Solano, John F. X. Diffley, Nynke H. Dekker
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Article Pages: 1 Open access contents
Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides
Alice L. B. Pyne, Agnes Noy, Kavit H. S. Main, Victor Velasco-Berrelleza, Michael M. Piperakis, Lesley A. Mitchenall, Fiorella M. Cugliandolo, Joseph G. Beton, Clare E. M. Stevenson, Bart W. Hoogenboom, Andrew D. Bates, Anthony Maxwell, Sarah A. Harris
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Article Pages: 1 Open access contents
Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection
Eric M. Mulhall, Andrew Ward, Darren Yang, Mounir A. Koussa, David P. Corey, Wesley P. Wong
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Article Pages: 1 Open access contents
Effects of individual base-pairs on in vivo target search and destruction kinetics of bacterial small RNA
Anustup Poddar, Muhammad S. Azam, Tunc Kayikcioglu, Maksym Bobrovskyy, Jichuan Zhang, Xiangqian Ma, Piyush Labhsetwar, Jingyi Fei, Digvijay Singh, Zaida Luthey-Schulten, Carin K. Vanderpool, Taekjip Ha
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Article Pages: 1 Open access contents