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Protein design and variant prediction using autoregressive generative models
Jung-Eun Shin, Adam J. Riesselman, Aaron W. Kollasch, Conor McMahon, Elana Simon, Chris Sander, Aashish Manglik, Andrew C. Kruse, Debora S. Marks
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Article Pages: 1 Open access contents
Design of multi-scale protein complexes by hierarchical building block fusion
Yang Hsia, Rubul Mout, William Sheffler, Natasha I. Edman, Ivan Vulovic, Young-Jun Park, Rachel L. Redler, Matthew J. Bick, Asim K. Bera, Alexis Courbet, Alex Kang, T. J. Brunette, Una Nattermann, Evelyn Tsai, Ayesha Saleem, Cameron M. Chow, Damian Ekiert, Gira Bhabha, David Veesler, David Baker
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Article Pages: 1 Open access contents
Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity
Tushar Modi, Valeria A. Risso, Sergio Martinez-Rodriguez, Jose A. Gavira, Mubark D. Mebrat, Wade D. Van Horn, Jose M. Sanchez-Ruiz, S. Banu Ozkan
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Article Pages: 1 Open access contents
Active-site loop variations adjust activity and selectivity of the cumene dioxygenase
Peter M. Heinemann, Daniel Armbruster, Bernhard Hauer
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Article Pages: 1 Open access contents
Designed folding pathway of modular coiled-coil-based proteins
Jana Aupič, Žiga Strmšek, Fabio Lapenta, David Pahovnik, Tomaž Pisanski, Igor Drobnak, Ajasja Ljubetič, Roman Jerala
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Article Pages: 1 Open access contents
Self-assembly and regulation of protein cages from pre-organised coiled-coil modules
Fabio Lapenta, Jana Aupič, Marco Vezzoli, Žiga Strmšek, Stefano Da Vela, Dmitri I. Svergun, José María Carazo, Roberto Melero, Roman Jerala
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Article Pages: 1 Open access contents
Incorporation of sensing modalities into de novo designed fluorescence-activating proteins
Jason C. Klima, Lindsey A. Doyle, Justin Daho Lee, Michael Rappleye, Lauren A. Gagnon, Min Yen Lee, Emilia P. Barros, Anastassia A. Vorobieva, Jiayi Dou, Samantha Bremner, Jacob S. Quon, Cameron M. Chow, Lauren Carter, David L. Mack, Rommie E. Amaro, Joshua C. Vaughan, Andre Berndt, Barry L. Stoddard, David Baker
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Article Pages: 1 Open access contents
NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins
Arne H. A. Scheu, Sheryl Y. T. Lim, Felix J. Metzner, Shabaz Mohammed, Mark Howarth
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Article Pages: 1 Open access contents
Direct control of CAR T cells through small molecule-regulated antibodies
Spencer Park, Edward Pascua, Kevin C. Lindquist, Christopher Kimberlin, Xiaodi Deng, Yvonne S. L. Mak, Zea Melton, Theodore O. Johnson, Regina Lin, Bijan Boldajipour, Robert T. Abraham, Jaume Pons, Barbra Johnson Sasu, Thomas J. Van Blarcom, Javier Chaparro-Riggers
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Article Pages: 1 Open access contents
Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase
Gloria Gamiz-Arco, Luis I. Gutierrez-Rus, Valeria A. Risso, Beatriz Ibarra-Molero, Yosuke Hoshino, Dušan Petrović, Jose Justicia, Juan Manuel Cuerva, Adrian Romero-Rivera, Burckhard Seelig, Jose A. Gavira, Shina C. L. Kamerlin, Eric A. Gaucher, Jose M. Sanchez-Ruiz
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Article Pages: 1 Open access contents