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Mediator subunit Med15 dictates the conserved “fuzzy” binding mechanism of yeast transcription activators Gal4 and Gcn4
Lisa M. Tuttle, Derek Pacheco, Linda Warfield, Damien B. Wilburn, Steven Hahn, Rachel E. Klevit
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Article Pages: 1 Open access contents
A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex
Alessio Fragasso, Hendrik W. de Vries, John Andersson, Eli O. van der Sluis, Erik van der Giessen, Andreas Dahlin, Patrick R. Onck, Cees Dekker
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Article Pages: 1 Open access contents
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
Jasmine Cubuk, Jhullian J. Alston, J. Jeremías Incicco, Sukrit Singh, Melissa D. Stuchell-Brereton, Michael D. Ward, Maxwell I. Zimmerman, Neha Vithani, Daniel Griffith, Jason A. Wagoner, Gregory R. Bowman, Kathleen B. Hall, Andrea Soranno, Alex S. Holehouse
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Article Pages: 1 Open access contents
A modular tool to query and inducibly disrupt biomolecular condensates
Carmen N. Hernández-Candia, Sarah Pearce, Chandra L. Tucker
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Article Pages: 1 Open access contents
Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
Kengo Watanabe, Kazuhiro Morishita, Xiangyu Zhou, Shigeru Shiizaki, Yasuo Uchiyama, Masato Koike, Isao Naguro, Hidenori Ichijo
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Article Pages: 1 Open access contents
Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures
Xin Dai, Wenhao Fu, Huanyu Chi, Vince St. Dollente Mesias, Hongni Zhu, Cheuk Wai Leung, Wei Liu, Jinqing Huang
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Article Pages: 1 Open access contents
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
Georg Krainer, Timothy J. Welsh, Jerelle A. Joseph, Jorge R. Espinosa, Sina Wittmann, Ella de Csilléry, Akshay Sridhar, Zenon Toprakcioglu, Giedre Gudiškytė, Magdalena A. Czekalska, William E. Arter, Jordina Guillén-Boixet, Titus M. Franzmann, Seema Qamar, Peter St George-Hyslop, Anthony A. Hyman, Rosana Collepardo-Guevara, Simon Alberti, Tuomas P. J. Knowles
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Article Pages: 1 Open access contents
EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction
Jing Zhao, Alan Blayney, Xiaorong Liu, Lauren Gandy, Weihua Jin, Lufeng Yan, Jeung-Hoi Ha, Ashley J. Canning, Michael Connelly, Chao Yang, Xinyue Liu, Yuanyuan Xiao, Michael S. Cosgrove, Sozanne R. Solmaz, Yingkai Zhang, David Ban, Jianhan Chen, Stewart N. Loh, Chunyu Wang
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Article Pages: 1 Open access contents
High resolution ensemble description of metamorphic and intrinsically disordered proteins using an efficient hybrid parallel tempering scheme
Rajeswari Appadurai, Jayashree Nagesh, Anand Srivastava
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Article Pages: 1 Open access contents
Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies
Taranpreet Kaur, Muralikrishna Raju, Ibraheem Alshareedah, Richoo B. Davis, Davit A. Potoyan, Priya R. Banerjee
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Article Pages: 1 Open access contents