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Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
Jang-June Park, Emily P. Thi, Victor H. Carpio, Yingzhi Bi, Andrew G. Cole, Bruce D. Dorsey, Kristi Fan, Troy Harasym, Christina L. Iott, Salam Kadhim, Jin Hyang Kim, Amy C. H. Lee, Duyan Nguyen, Bhavna S. Paratala, Ruiqing Qiu, Andre White, Damodharan Lakshminarasimhan, Christopher Leo, Robert K. Suto, Rene Rijnbrand, Sunny Tang, Michael J. Sofia, Chris B. Moore
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Article Pages: 1 Open access contents
Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells
Rebekka Duhen, Carmen Ballesteros-Merino, Alexandra K. Frye, Eric Tran, Venkatesh Rajamanickam, Shu-Ching Chang, Yoshinobu Koguchi, Carlo B. Bifulco, Brady Bernard, Rom S. Leidner, Brendan D. Curti, Bernard A. Fox, Walter J. Urba, R. Bryan Bell, Andrew D. Weinberg
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Article Pages: 1 Open access contents
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
Alba Rodriguez-Garcia, Rachel C. Lynn, Mathilde Poussin, Monika A. Eiva, Lauren C. Shaw, Roddy S. O’Connor, Nicholas G. Minutolo, Victoria Casado-Medrano, Gonzalo Lopez, Takami Matsuyama, Daniel J. Powell
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Article Pages: 1 Open access contents
Engineering advanced logic and distributed computing in human CAR immune cells
Jang Hwan Cho, Atsushi Okuma, Katri Sofjan, Seunghee Lee, James J. Collins, Wilson W. Wong
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Article Pages: 1 Open access contents
High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming
Guangan Hu, Yang Su, Byong Ha Kang, Zhongqi Fan, Ting Dong, Douglas R. Brown, Jaime Cheah, Karl Dane Wittrup, Jianzhu Chen
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Article Pages: 1 Open access contents
A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy
Laetitia Douguet, Serena Janho dit Hreich, Jonathan Benzaquen, Laetitia Seguin, Thierry Juhel, Xavier Dezitter, Christophe Duranton, Bernhard Ryffel, Jean Kanellopoulos, Cecile Delarasse, Nicolas Renault, Christophe Furman, Germain Homerin, Chloé Féral, Julien Cherfils-Vicini, Régis Millet, Sahil Adriouch, Alina Ghinet, Paul Hofman, Valérie Vouret-Craviari
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Article Pages: 1 Open access contents
Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma
Giulia Agliardi, Anna Rita Liuzzi, Alastair Hotblack, Donatella De Feo, Nicolás Núñez, Cassandra L. Stowe, Ekaterina Friebel, Francesco Nannini, Lukas Rindlisbacher, Thomas A. Roberts, Rajiv Ramasawmy, Iwan P. Williams, Bernard M. Siow, Mark F. Lythgoe, Tammy L. Kalber, Sergio A. Quezada, Martin A. Pule, Sonia Tugues, Karin Straathof, Burkhard Becher
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Article Pages: 1 Open access contents
An IgG‐based bispecific antibody for improved dual targeting in PSMA‐positive cancer
Latifa Zekri, Fabian Vogt, Lukas Osburg, Stefanie Müller, Joseph Kauer, Timo Manz, Martin Pflügler, Andreas Maurer, Jonas S Heitmann, Ilona Hagelstein, Melanie Märklin, Sebastian Hörner, Tilmann Todenhöfer, Carsten Calaminus, Arnulf Stenzl, Bernd Pichler, Christian la Fougère, Marc A Schneider, Hans‐Georg Rammensee, Lars Zender, Bence Sipos, Helmut R Salih, Gundram Jung
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Article Pages: 1 Open access contents
Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer
Weiqiang Lu, Weiwei Yu, Jiacheng He, Wenjuan Liu, Junjie Yang, Xianhua Lin, Yuanjin Zhang, Xin Wang, Wenhao Jiang, Jian Luo, Qiansen Zhang, Huaiyu Yang, Shihong Peng, Zhengfang Yi, Shancheng Ren, Jing Chen, Stefan Siwko, Ruth Nussinov, Feixiong Cheng, Hankun Zhang, Mingyao Liu
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Article Pages: 1 Open access contents
Isatuximab plus pomalidomide and dexamethasone in relapsed/refractory multiple myeloma patients with renal impairment: ICARIA-MM subgroup analysis
Meletios A. Dimopoulos, Xavier Leleu, Philippe Moreau, Paul G. Richardson, Anna Marina Liberati, Simon J. Harrison, H. Miles Prince, Enrique M. Ocio, Sylvie Assadourian, Frank Campana, Laure Malinge, Dorothée Sémiond, Helgi van de Velde, Kwee Yong
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Article Pages: 10 Open access contents