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Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase
Jing Li, Barun Mahata, Mario Escobar, Jacob Goell, Kaiyuan Wang, Pranav Khemka, Isaac B. Hilton
Publication Date: 09 February, 2021
Article Pages: 1 Open access contents
Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy
Miles K. Huseyin, Robert J. Klose
Publication Date: 09 February, 2021
Article Pages: 1 Open access contents
L1 retrotransposons exploit RNA m<sup>6</sup>A modification as an evolutionary driving force
Sung-Yeon Hwang, Hyunchul Jung, Seyoung Mun, Sungwon Lee, Kiwon Park, S. Chan Baek, Hyungseok C. Moon, Hyewon Kim, Baekgyu Kim, Yongkuk Choi, Young-Hyun Go, Wanxiangfu Tang, Jongsu Choi, Jung Kyoon Choi, Hyuk-Jin Cha, Hye Yoon Park, Ping Liang, V. Narry Kim, Kyudong Han, Kwangseog Ahn
Publication Date: 09 February, 2021
Article Pages: 1 Open access contents
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide
Fei Li, Ming Han, Pengfei Dai, Wei Xu, Juan He, Xiaoting Tao, Yang Wu, Xinyuan Tong, Xinyi Xia, Wangxin Guo, Yunjiao Zhou, Yunguang Li, Yiqin Zhu, Xiaoyu Zhang, Zhuang Liu, Rebiguli Aji, Xia Cai, Yutang Li, Di Qu, Yu Chen, Shibo Jiang, Qiao Wang, Hongbin Ji, Youhua Xie, Yihua Sun, Lu Lu, Dong Gao
Publication Date: 08 February, 2021
Article Pages: 1 Open access contents
H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
Yichao Cai, Ying Zhang, Yan Ping Loh, Jia Qi Tng, Mei Chee Lim, Zhendong Cao, Anandhkumar Raju, Erez Lieberman Aiden, Shang Li, Lakshmanan Manikandan, Vinay Tergaonkar, Greg Tucker-Kellogg, Melissa Jane Fullwood
Publication Date: 29 January, 2021
Article Pages: 1 Open access contents
Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation
Roser Vilarrasa-Blasi, Paula Soler-Vila, Núria Verdaguer-Dot, Núria Russiñol, Marco Di Stefano, Vicente Chapaprieta, Guillem Clot, Irene Farabella, Pol Cuscó, Marta Kulis, Xabier Agirre, Felipe Prosper, Renée Beekman, Silvia Beà, Dolors Colomer, Hendrik G. Stunnenberg, Ivo Gut, Elias Campo, Marc A. Marti-Renom, José Ignacio Martin-Subero
Publication Date: 28 January, 2021
Article Pages: 1 Open access contents
LEAFY is a pioneer transcription factor and licenses cell reprogramming to floral fate
Run Jin, Samantha Klasfeld, Yang Zhu, Meilin Fernandez Garcia, Jun Xiao, Soon-Ki Han, Adam Konkol, Doris Wagner
Publication Date: 27 January, 2021
Article Pages: 1 Open access contents
Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals
Azad Alizada, Nadiya Khyzha, Liangxi Wang, Lina Antounians, Xiaoting Chen, Melvin Khor, Minggao Liang, Kumaragurubaran Rathnakumar, Matthew T. Weirauch, Alejandra Medina-Rivera, Jason E. Fish, Michael D. Wilson
Publication Date: 25 January, 2021
Article Pages: 1 Open access contents
Nanobody-mediated control of gene expression and epigenetic memory
Mike V. Van, Taihei Fujimori, Lacramioara Bintu
Publication Date: 22 January, 2021
Article Pages: 1 Open access contents
High-resolution targeted 3C interrogation of <i>cis</i>-regulatory element organization at genome-wide scale
Damien J. Downes, Robert A. Beagrie, Matthew E. Gosden, Jelena Telenius, Stephanie J. Carpenter, Lea Nussbaum, Sara De Ornellas, Martin Sergeant, Chris Q. Eijsbouts, Ron Schwessinger, Jon Kerry, Nigel Roberts, Arun Shivalingam, Afaf El-Sagheer, A. Marieke Oudelaar, Tom Brown, Veronica J. Buckle, James O. J. Davies, Jim R. Hughes
Publication Date: 22 January, 2021
Article Pages: 1 Open access contents
Large organized chromatin lysine domains help distinguish primitive from differentiated cell populations
Seyed Ali Madani Tonekaboni, Benjamin Haibe-Kains, Mathieu Lupien
Publication Date: 21 January, 2021
Article Pages: 1 Open access contents
Dissection of the <i>Fgf8</i> regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy
A. Hörnblad, S. Bastide, K. Langenfeld, F. Langa, F. Spitz
Publication Date: 19 January, 2021
Article Pages: 1 Open access contents
Dual RNA 3’-end processing of H2A.X messenger RNA maintains DNA damage repair throughout the cell cycle
Esther Griesbach, Margarita Schlackow, William F. Marzluff, Nick J. Proudfoot
Publication Date: 13 January, 2021
Article Pages: 1 Open access contents
Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems
Timothy C. Yu, Winnie L. Liu, Marcia S. Brinck, Jessica E. Davis, Jeremy Shek, Grace Bower, Tal Einav, Kimberly D. Insigne, Rob Phillips, Sriram Kosuri, Guillaume Urtecho
Publication Date: 12 January, 2021
Article Pages: 1 Open access contents
Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes
Tianxiong Yu, Kaili Fan, Deniz M. Özata, Gen Zhang, Yu Fu, William E. Theurkauf, Phillip D. Zamore, Zhiping Weng
Publication Date: 04 January, 2021
Article Pages: 1 Open access contents
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