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Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis
Madhuranayaki Thulasingam, Laura Orellana, Emmanuel Nji, Shabbir Ahmad, Agnes Rinaldo-Matthis, Jesper Z. Haeggström
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Article Pages: 1 Open access contents
Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
Raminta Venskutonytė, Ara Koh, Olof Stenström, Muhammad Tanweer Khan, Annika Lundqvist, Mikael Akke, Fredrik Bäckhed, Karin Lindkvist-Petersson
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Article Pages: 1 Open access contents
Structure-guided insights into heterocyclic ring-cleavage catalysis of the non-heme Fe (II) dioxygenase NicX
Gongquan Liu, Yi-Lei Zhao, Fangyuan He, Peng Zhang, Xingyu Ouyang, Hongzhi Tang, Ping Xu
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Article Pages: 1 Open access contents
Discovery of exolytic heparinases and their catalytic mechanism and potential application
Qingdong Zhang, Hai-Yan Cao, Lin Wei, Danrong Lu, Min Du, Min Yuan, Deling Shi, Xiangxue Chen, Peng Wang, Xiu-Lan Chen, Lianli Chi, Yu-Zhong Zhang, Fuchuan Li
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Article Pages: 1 Open access contents
A rotary mechanism for allostery in bacterial hybrid malic enzymes
Christopher John Harding, Ian Thomas Cadby, Patrick Joseph Moynihan, Andrew Lee Lovering
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Article Pages: 1 Open access contents
RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination
Leo Kiss, Dean Clift, Nadine Renner, David Neuhaus, Leo C. James
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Article Pages: 1 Open access contents
Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice
Iain W. McNae, James Kinkead, Divya Malik, Li-Hsuan Yen, Martin K. Walker, Chris Swain, Scott P. Webster, Nick Gray, Peter M. Fernandes, Elmarie Myburgh, Elizabeth A. Blackburn, Ryan Ritchie, Carol Austin, Martin A. Wear, Adrian J. Highton, Andrew J. Keats, Antonio Vong, Jacqueline Dornan, Jeremy C. Mottram, Paul A. M. Michels, Simon Pettit, Malcolm D. Walkinshaw
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Article Pages: 1 Open access contents
Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase
Leo Bellin, Francisco Del Caño-Ochoa, Adrián Velázquez-Campoy, Torsten Möhlmann, Santiago Ramón-Maiques
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Article Pages: 1 Open access contents
Functional and structural characterization of a flavoprotein monooxygenase essential for biogenesis of tryptophylquinone cofactor
Toshinori Oozeki, Tadashi Nakai, Kazuki Kozakai, Kazuki Okamoto, Shun’ichi Kuroda, Kazuo Kobayashi, Katsuyuki Tanizawa, Toshihide Okajima
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Article Pages: 1 Open access contents
Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria
Gaohua Yang, Sen Hong, Pengjie Yang, Yuwei Sun, Yong Wang, Peng Zhang, Weihong Jiang, Yang Gu
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Article Pages: 1 Open access contents