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RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination
Leo Kiss, Dean Clift, Nadine Renner, David Neuhaus, Leo C. James
Publication Date: 22 February, 2021
Article Pages: 1 Open access contents
Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice
Iain W. McNae, James Kinkead, Divya Malik, Li-Hsuan Yen, Martin K. Walker, Chris Swain, Scott P. Webster, Nick Gray, Peter M. Fernandes, Elmarie Myburgh, Elizabeth A. Blackburn, Ryan Ritchie, Carol Austin, Martin A. Wear, Adrian J. Highton, Andrew J. Keats, Antonio Vong, Jacqueline Dornan, Jeremy C. Mottram, Paul A. M. Michels, Simon Pettit, Malcolm D. Walkinshaw
Publication Date: 16 February, 2021
Article Pages: 1 Open access contents
Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase
Leo Bellin, Francisco Del Caño-Ochoa, Adrián Velázquez-Campoy, Torsten Möhlmann, Santiago Ramón-Maiques
Publication Date: 11 February, 2021
Article Pages: 1 Open access contents
Functional and structural characterization of a flavoprotein monooxygenase essential for biogenesis of tryptophylquinone cofactor
Toshinori Oozeki, Tadashi Nakai, Kazuki Kozakai, Kazuki Okamoto, Shun’ichi Kuroda, Kazuo Kobayashi, Katsuyuki Tanizawa, Toshihide Okajima
Publication Date: 10 February, 2021
Article Pages: 1 Open access contents
Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria
Gaohua Yang, Sen Hong, Pengjie Yang, Yuwei Sun, Yong Wang, Peng Zhang, Weihong Jiang, Yang Gu
Publication Date: 04 February, 2021
Article Pages: 1 Open access contents
The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases
Janne J. Mäkinen, Yeonoh Shin, Eeva Vieras, Pasi Virta, Mikko Metsä-Ketelä, Katsuhiko S. Murakami, Georgiy A. Belogurov
Publication Date: 04 February, 2021
Article Pages: 1 Open access contents
A safety cap protects hydrogenase from oxygen attack
Martin Winkler, Jifu Duan, Andreas Rutz, Christina Felbek, Lisa Scholtysek, Oliver Lampret, Jan Jaenecke, Ulf-Peter Apfel, Gianfranco Gilardi, Francesca Valetti, Vincent Fourmond, Eckhard Hofmann, Christophe Léger, Thomas Happe
Publication Date: 02 February, 2021
Article Pages: 1 Open access contents
Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs
Johannes Rudolph, Genevieve Roberts, Karolin Luger
Publication Date: 02 February, 2021
Article Pages: 1 Open access contents
APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
Tung-Chang Liu, Chun-Ting Lin, Kai-Cheng Chang, Kai-Wei Guo, Shuying Wang, Jhih-Wei Chu, Yu-Yuan Hsiao
Publication Date: 27 January, 2021
Article Pages: 1 Open access contents
Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1
Jiqing Du, Marie-Kristin von Wrisberg, Burak Gulen, Matthias Stahl, Christian Pett, Christian Hedberg, Kathrin Lang, Sabine Schneider, Aymelt Itzen
Publication Date: 19 January, 2021
Article Pages: 1 Open access contents
Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism
Yufei Han, Qian Zhuang, Bo Sun, Wenping Lv, Sheng Wang, Qingjie Xiao, Bin Pang, Youli Zhou, Fuxing Wang, Pengliang Chi, Qisheng Wang, Zhen Li, Lizhe Zhu, Fuping Li, Dong Deng, Ying-Chih Chiang, Zhenfei Li, Ruobing Ren
Publication Date: 19 January, 2021
Article Pages: 1 Open access contents
Two distinct catalytic pathways for GH43 xylanolytic enzymes unveiled by X-ray and QM/MM simulations
Mariana A. B. Morais, Joan Coines, Mariane N. Domingues, Renan A. S. Pirolla, Celisa C. C. Tonoli, Camila R. Santos, Jessica B. L. Correa, Fabio C. Gozzo, Carme Rovira, Mario T. Murakami
Publication Date: 14 January, 2021
Article Pages: 1 Open access contents
Structure of a full-length bacterial polysaccharide co-polymerase
Benjamin Wiseman, Ram Gopal Nitharwal, Göran Widmalm, Martin Högbom
Publication Date: 14 January, 2021
Article Pages: 1 Open access contents
Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis
Lin Zhong, Xiaotong Diao, Na Zhang, Fengwei Li, Haibo Zhou, Hanna Chen, Xianping Bai, Xintong Ren, Youming Zhang, Dalei Wu, Xiaoying Bian
Publication Date: 12 January, 2021
Article Pages: 1 Open access contents
Insights into genome recoding from the mechanism of a classic +1-frameshifting tRNA
Howard Gamper, Haixing Li, Isao Masuda, D. Miklos Robkis, Thomas Christian, Adam B. Conn, Gregor Blaha, E. James Petersson, Ruben L. Gonzalez, Ya-Ming Hou
Publication Date: 12 January, 2021
Article Pages: 1 Open access contents
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