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Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex
Joy Y. Wang, Christopher M. Hoel, Basem Al-Shayeb, Jillian F. Banfield, Stephen G. Brohawn, Jennifer A. Doudna
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Article Pages: 1 Open access contents
Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity
Thierry Izoré, Y. T. Candace Ho, Joe A. Kaczmarski, Athina Gavriilidou, Ka Ho Chow, David L. Steer, Robert J. A. Goode, Ralf B. Schittenhelm, Julien Tailhades, Manuela Tosin, Gregory L. Challis, Elizabeth H. Krenske, Nadine Ziemert, Colin J. Jackson, Max J. Cryle
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Article Pages: 1 Open access contents
Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD
Joel Fauser, Burak Gulen, Vivian Pogenberg, Christian Pett, Danial Pourjafar-Dehkordi, Christoph Krisp, Dorothea Höpfner, Gesa König, Hartmut Schlüter, Matthias J. Feige, Martin Zacharias, Christian Hedberg, Aymelt Itzen
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Article Pages: 1 Open access contents
Crystal structures of an E1–E2–ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification
Lingmin Yuan, Zongyang Lv, Melanie J. Adams, Shaun K. Olsen
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Article Pages: 1 Open access contents
Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase
Simon Bo Jensen, Sara Thodberg, Shaheena Parween, Matias E. Moses, Cecilie C. Hansen, Johannes Thomsen, Magnus B. Sletfjerding, Camilla Knudsen, Rita Del Giudice, Philip M. Lund, Patricia R. Castaño, Yanet G. Bustamante, Maria Natalia Rojas Velazquez, Flemming Steen Jørgensen, Amit V. Pandey, Tomas Laursen, Birger Lindberg Møller, Nikos S. Hatzakis
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Article Pages: 1 Open access contents
Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1
Sabine Ruegenberg, Felix A. M. C. Mayr, Ilian Atanassov, Ulrich Baumann, Martin S. Denzel
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Article Pages: 1 Open access contents
Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase
Raphael D. Teixeira, Fabian Holzschuh, Tilman Schirmer
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Article Pages: 1 Open access contents
Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase
Jahaun Azadmanesh, William E. Lutz, Leighton Coates, Kevin L. Weiss, Gloria E. O. Borgstahl
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Article Pages: 1 Open access contents
Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
Joonas A. Jamsen, Akira Sassa, David D. Shock, William A. Beard, Samuel H. Wilson
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Article Pages: 1 Open access contents
Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway
Sitao Zhang, Yongchang Xu, Hongxin Guan, Tao Cui, Yuling Liao, Wenhui Wei, Jun Li, Bachar H. Hassan, Huimin Zhang, Xu Jia, Songying Ouyang, Youjun Feng
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Article Pages: 1 Open access contents