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Structural insights into TSC complex assembly and GAP activity on Rheb
Huirong Yang, Zishuo Yu, Xizi Chen, Jiabei Li, Ningning Li, Jiaxuan Cheng, Ning Gao, Hai-Xin Yuan, Dan Ye, Kun-Liang Guan, Yanhui Xu
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Article Pages: 1 Open access contents
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
Goran Kokic, Hauke S. Hillen, Dimitry Tegunov, Christian Dienemann, Florian Seitz, Jana Schmitzova, Lucas Farnung, Aaron Siewert, Claudia Höbartner, Patrick Cramer
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Article Pages: 1 Open access contents
Stabilizing the closed SARS-CoV-2 spike trimer
Jarek Juraszek, Lucy Rutten, Sven Blokland, Pascale Bouchier, Richard Voorzaat, Tina Ritschel, Mark J. G. Bakkers, Ludovic L. R. Renault, Johannes P. M. Langedijk
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Article Pages: 1 Open access contents
Cryo-EM structure of <i>Helicobacter pylori</i> urease with an inhibitor in the active site at 2.0 Å resolution
Eva S. Cunha, Xiaorui Chen, Marta Sanz-Gaitero, Deryck J. Mills, Hartmut Luecke
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Article Pages: 1 Open access contents
Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes
Xiyong Song, Yuejun Shi, Wei Ding, Tongxin Niu, Limeng Sun, Yubei Tan, Yong Chen, Jiale Shi, Qiqi Xiong, Xiaojun Huang, Shaobo Xiao, Yanping Zhu, Chongyun Cheng, Zhen F. Fu, Zhi-Jie Liu, Guiqing Peng
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Article Pages: 1 Open access contents
Structures of human dual oxidase 1 complex in low-calcium and high-calcium states
Jing-Xiang Wu, Rui Liu, Kangcheng Song, Lei Chen
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Article Pages: 1 Open access contents
Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8
Qin Gong, Kim Robinson, Chenrui Xu, Phuong Thao Huynh, Kelvin Han Chung Chong, Eddie Yong Jun Tan, Jiawen Zhang, Zhao Zhi Boo, Daniel Eng Thiam Teo, Kenneth Lay, Yaming Zhang, John Soon Yew Lim, Wah Ing Goh, Graham Wright, Franklin L. Zhong, Bruno Reversade, Bin Wu
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Article Pages: 1 Open access contents
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes
L. Robert Hollingsworth, Liron David, Yang Li, Andrew R. Griswold, Jianbin Ruan, Humayun Sharif, Pietro Fontana, Elizabeth L. Orth-He, Tian-Min Fu, Daniel A. Bachovchin, Hao Wu
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Article Pages: 1 Open access contents
ATP synthase hexamer assemblies shape cristae of <i>Toxoplasma</i> mitochondria
Alexander Mühleip, Rasmus Kock Flygaard, Jana Ovciarikova, Alice Lacombe, Paula Fernandes, Lilach Sheiner, Alexey Amunts
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Article Pages: 1 Open access contents
Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative
Man Pan, Qingyun Zheng, Yuanyuan Yu, Huasong Ai, Yuan Xie, Xin Zeng, Chu Wang, Lei Liu, Minglei Zhao
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Article Pages: 1 Open access contents