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Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
Rebecca E. Graff, Taylor B. Cavazos, Khanh K. Thai, Linda Kachuri, Sara R. Rashkin, Joshua D. Hoffman, Stacey E. Alexeeff, Maruta Blatchins, Travis J. Meyers, Lancelote Leong, Caroline G. Tai, Nima C. Emami, Douglas A. Corley, Lawrence H. Kushi, Elad Ziv, Stephen K. Van Den Eeden, Eric Jorgenson, Thomas J. Hoffmann, Laurel A. Habel, John S. Witte, Lori C. Sakoda
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Article Pages: 1 Open access contents
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer
Tiziano Bernasocchi, Geniver El Tekle, Marco Bolis, Azzurra Mutti, Arianna Vallerga, Laura P. Brandt, Filippo Spriano, Tanya Svinkina, Marita Zoma, Valentina Ceserani, Anna Rinaldi, Hana Janouskova, Daniela Bossi, Manuela Cavalli, Simone Mosole, Roger Geiger, Ze Dong, Cai-Guang Yang, Domenico Albino, Andrea Rinaldi, Peter Schraml, Simon Linder, Giuseppina M. Carbone, Andrea Alimonti, Francesco Bertoni, Holger Moch, Steven A. Carr, Wilbert Zwart, Marianna Kruithof-de Julio, Mark A. Rubin, Namrata D. Udeshi, Jean-Philippe P. Theurillat
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Article Pages: 1 Open access contents
Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors
Cristina Valero, Mark Lee, Douglas Hoen, Kate Weiss, Daniel W. Kelly, Prasad S. Adusumilli, Paul K. Paik, George Plitas, Marc Ladanyi, Michael A. Postow, Charlotte E. Ariyan, Alexander N. Shoushtari, Vinod P. Balachandran, A. Ari Hakimi, Aimee M. Crago, Kara C. Long Roche, J. Joshua Smith, Ian Ganly, Richard J. Wong, Snehal G. Patel, Jatin P. Shah, Nancy Y. Lee, Nadeem Riaz, Jingming Wang, Ahmet Zehir, Michael F. Berger, Timothy A. Chan, Venkatraman E. Seshan, Luc G. T. Morris
Publication Date:
Article Pages: 1 Open access contents
Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia
Wei-Yu Lin, Sarah E. Fordham, Nicola Sunter, Claire Elstob, Thahira Rahman, Elaine Willmore, Colin Shepherd, Gordon Strathdee, Tryfonia Mainou-Fowler, Rachel Piddock, Hannah Mearns, Timothy Barrow, Richard S. Houlston, Helen Marr, Jonathan Wallis, Geoffrey Summerfield, Scott Marshall, Andrew Pettitt, Christopher Pepper, Christopher Fegan, Francesco Forconi, Martin J. S. Dyer, Sandrine Jayne, April Sellors, Anna Schuh, Pauline Robbe, David Oscier, James Bailey, Syed Rais, Alison Bentley, Lynn Cawkwell, Paul Evans, Peter Hillmen, Guy Pratt, David J. Allsup, James M. Allan
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Article Pages: 1 Open access contents
Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres
Timothy P. Lippert, Paulina Marzec, Aurora I. Idilli, Grzegorz Sarek, Aleksandra Vancevska, Mark Bower, Paul J. Farrell, Päivi M. Ojala, Niklas Feldhahn, Simon J. Boulton
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Article Pages: 1 Open access contents
A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization
Jue-Sheng Ong, Suzanne C. Dixon-Suen, Xikun Han, Jiyuan An, Rebecca Fitzgerald, Matt Buas, Marilie D. Gammon, Douglas A. Corley, Nicholas J. Shaheen, Laura J. Hardie, Nigel C. Bird, Brian J. Reid, Wong-Ho Chow, Harvey A. Risch, Weimin Ye, Geoffrey Liu, Yvonne Romero, Leslie Bernstein, Anna H. Wu, David E. Whiteman, Thomas Vaughan, M. Agee, B. Alipanahi, A. Auton, R. K. Bell, K. Bryc, S. L. Elson, P. Fontanillas, N. A. Furlotte, D. A. Hinds, K. E. Huber, A. Kleinman, N. K. Litterman, M. H. McIntyre, J. L. Mountain, E. S. Noblin, C. A. M. Northover, S. J. Pitts, J. Fah Sathirapongsasuti, O. V. Sazonova, J. F. Shelton, S. Shringarpure, C. Tian, J. Y. Tung, V. Vacic, C. H. Wilson, Upekha Liyanage, Jean-Cluade Dusingize, Johannes Schumacher, Ines Gockel, Anne Böhmer, Janusz Jankowski, Claire Palles, Tracy O’Mara, Amanda Spurdle, Matthew H. Law, Mark M. Iles, Paul Pharoah, Andrew Berchuck, Wei Zheng, Aaron P. Thrift, Catherine Olsen, Rachel E. Neale, Puya Gharahkhani, Penelope M. Webb, Stuart MacGregor
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Article Pages: 1 Open access contents
KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway
Wenwen Du, Jianjie Zhu, Yuanyuan Zeng, Ting Liu, Yang Zhang, Tingting Cai, Yulong Fu, Weijie Zhang, Ruochen Zhang, Zeyi Liu, Jian-an Huang
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Article Pages: 16 Open access contents
Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility
Mateus H. Gouveia, Isaac Otim, Martin D. Ogwang, Mingyi Wang, Bin Zhu, Nathan Cole, Wen Luo, Belynda Hicks, Kristine Jones, Kathrin Oehl-Huber, Leona W. Ayers, Stefania Pittaluga, Ismail D. Legason, Hadijah Nabalende, Patrick Kerchan, Tobias Kinyera, Esther Kawira, Glen Brubaker, Arthur G. Levin, Lutz Guertler, Jung Kim, Douglas R. Stewart, Melissa Adde, Ian Magrath, Andrew W. Bergen, Steven J. Reynolds, Meredith Yeager, Kishor Bhatia, Adebowale A. Adeyemo, Ludmila Prokunina-Olsson, Michael Dean, Daniel Shriner, Charles N. Rotimi, Stephen Chanock, Reiner Siebert, Sam M. Mbulaiteye
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Article Pages: 4 Open access contents
Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks
Lars G. Fritsche, Snehal Patil, Lauren J. Beesley, Peter VandeHaar, Maxwell Salvatore, Ying Ma, Robert B. Peng, Daniel Taliun, Xiang Zhou, Bhramar Mukherjee
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Article Pages: 21 Open access contents
<i>RUNX1</i> mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses
Shady Adnan Awad, Olli Dufva, Aleksandr Ianevski, Bishwa Ghimire, Jan Koski, Pilvi Maliniemi, Daniel Thomson, Andreas Schreiber, Caroline A. Heckman, Perttu Koskenvesa, Matti Korhonen, Kimmo Porkka, Susan Branford, Tero Aittokallio, Matti Kankainen, Satu Mustjoki
Publication Date:
Article Pages: 12 Open access contents