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A clinical transcriptome approach to patient stratification and therapy selection in acute myeloid leukemia
T. Roderick Docking, Jeremy D. K. Parker, Martin Jädersten, Gerben Duns, Linda Chang, Jihong Jiang, Jessica A. Pilsworth, Lucas A. Swanson, Simon K. Chan, Readman Chiu, Ka Ming Nip, Samantha Mar, Angela Mo, Xuan Wang, Sergio Martinez-Høyer, Ryan J. Stubbins, Karen L. Mungall, Andrew J. Mungall, Richard A. Moore, Steven J. M. Jones, İnanç Birol, Marco A. Marra, Donna Hogge, Aly Karsan
Publication Date: 30 April, 2021
Article Pages: 1 Open access contents
Genomic profile of advanced breast cancer in circulating tumour DNA
Belinda Kingston, Rosalind J. Cutts, Hannah Bye, Matthew Beaney, Giselle Walsh-Crestani, Sarah Hrebien, Claire Swift, Lucy S. Kilburn, Sarah Kernaghan, Laura Moretti, Katie Wilkinson, Andrew M. Wardley, Iain R. Macpherson, Richard D. Baird, Rebecca Roylance, Jorge S. Reis-Filho, Michael Hubank, Iris Faull, Kimberly C. Banks, Richard B. Lanman, Isaac Garcia-Murillas, Judith M. Bliss, Alistair Ring, Nicholas C. Turner
Publication Date: 23 April, 2021
Article Pages: 1 Open access contents
Diagnostic and therapeutic pitfalls in <i>NPM1</i>-mutated AML: notes from the field
Brunangelo Falini, Sofia Sciabolacci, Lorenza Falini, Lorenzo Brunetti, Maria Paola Martelli
Publication Date: 20 April, 2021
Article Pages: 13 Open access contents
RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways
Victoria Gudiño, Sebastian Öther-Gee Pohl, Caroline V. Billard, Patrizia Cammareri, Alfonso Bolado, Stuart Aitken, David Stevenson, Adam E. Hall, Mark Agostino, John Cassidy, Colin Nixon, Alex von Kriegsheim, Paz Freile, Linda Popplewell, George Dickson, Laura Murphy, Ann Wheeler, Malcolm Dunlop, Farhat Din, Douglas Strathdee, Owen J. Sansom, Kevin B. Myant
Publication Date: 20 April, 2021
Article Pages: 1 Open access contents
Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
Pengpeng Liu, Shun-Qing Liang, Chunwei Zheng, Esther Mintzer, Yan G. Zhao, Karthikeyan Ponnienselvan, Aamir Mir, Erik J. Sontheimer, Guangping Gao, Terence R. Flotte, Scot A. Wolfe, Wen Xue
Publication Date: 09 April, 2021
Article Pages: 1 Open access contents
The origins and genetic interactions of <i>KRAS</i> mutations are allele- and tissue-specific
Joshua H. Cook, Giorgio E. M. Melloni, Doga C. Gulhan, Peter J. Park, Kevin M. Haigis
Publication Date: 22 March, 2021
Article Pages: 1 Open access contents
Beyond DNA repair and chromosome instability—Fanconi anaemia as a cellular senescence-associated syndrome
Anne Helbling-Leclerc, Cécile Garcin, Filippo Rosselli
Publication Date: 15 March, 2021
Article Pages: 14 Open access contents
Molecular biology of Hodgkin lymphoma
Marc A. Weniger, Ralf Küppers
Publication Date: 08 March, 2021
Article Pages: 13 Open access contents
Retroviral integrations contribute to elevated host cancer rates during germline invasion
Gayle K. McEwen, David E. Alquezar-Planas, Anisha Dayaram, Amber Gillett, Rachael Tarlinton, Nigel Mongan, Keith J. Chappell, Joerg Henning, Milton Tan, Peter Timms, Paul R. Young, Alfred L. Roca, Alex D. Greenwood
Publication Date: 26 February, 2021
Article Pages: 1 Open access contents
The association between deaths from infection and mutations of the <i>BRAF, FBXW7, NRAS and XPO1</i> genes: a report from the LRF CLL4 trial
Monica Else, Stuart J. Blakemore, Jonathan C. Strefford, Daniel Catovsky
Publication Date: 12 February, 2021
Article Pages: 6 Open access contents
Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
Rebecca E. Graff, Taylor B. Cavazos, Khanh K. Thai, Linda Kachuri, Sara R. Rashkin, Joshua D. Hoffman, Stacey E. Alexeeff, Maruta Blatchins, Travis J. Meyers, Lancelote Leong, Caroline G. Tai, Nima C. Emami, Douglas A. Corley, Lawrence H. Kushi, Elad Ziv, Stephen K. Van Den Eeden, Eric Jorgenson, Thomas J. Hoffmann, Laurel A. Habel, John S. Witte, Lori C. Sakoda
Publication Date: 12 February, 2021
Article Pages: 1 Open access contents
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer
Tiziano Bernasocchi, Geniver El Tekle, Marco Bolis, Azzurra Mutti, Arianna Vallerga, Laura P. Brandt, Filippo Spriano, Tanya Svinkina, Marita Zoma, Valentina Ceserani, Anna Rinaldi, Hana Janouskova, Daniela Bossi, Manuela Cavalli, Simone Mosole, Roger Geiger, Ze Dong, Cai-Guang Yang, Domenico Albino, Andrea Rinaldi, Peter Schraml, Simon Linder, Giuseppina M. Carbone, Andrea Alimonti, Francesco Bertoni, Holger Moch, Steven A. Carr, Wilbert Zwart, Marianna Kruithof-de Julio, Mark A. Rubin, Namrata D. Udeshi, Jean-Philippe P. Theurillat
Publication Date: 02 February, 2021
Article Pages: 1 Open access contents
Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors
Cristina Valero, Mark Lee, Douglas Hoen, Kate Weiss, Daniel W. Kelly, Prasad S. Adusumilli, Paul K. Paik, George Plitas, Marc Ladanyi, Michael A. Postow, Charlotte E. Ariyan, Alexander N. Shoushtari, Vinod P. Balachandran, A. Ari Hakimi, Aimee M. Crago, Kara C. Long Roche, J. Joshua Smith, Ian Ganly, Richard J. Wong, Snehal G. Patel, Jatin P. Shah, Nancy Y. Lee, Nadeem Riaz, Jingming Wang, Ahmet Zehir, Michael F. Berger, Timothy A. Chan, Venkatraman E. Seshan, Luc G. T. Morris
Publication Date: 01 February, 2021
Article Pages: 1 Open access contents
Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia
Wei-Yu Lin, Sarah E. Fordham, Nicola Sunter, Claire Elstob, Thahira Rahman, Elaine Willmore, Colin Shepherd, Gordon Strathdee, Tryfonia Mainou-Fowler, Rachel Piddock, Hannah Mearns, Timothy Barrow, Richard S. Houlston, Helen Marr, Jonathan Wallis, Geoffrey Summerfield, Scott Marshall, Andrew Pettitt, Christopher Pepper, Christopher Fegan, Francesco Forconi, Martin J. S. Dyer, Sandrine Jayne, April Sellors, Anna Schuh, Pauline Robbe, David Oscier, James Bailey, Syed Rais, Alison Bentley, Lynn Cawkwell, Paul Evans, Peter Hillmen, Guy Pratt, David J. Allsup, James M. Allan
Publication Date: 28 January, 2021
Article Pages: 1 Open access contents
Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres
Timothy P. Lippert, Paulina Marzec, Aurora I. Idilli, Grzegorz Sarek, Aleksandra Vancevska, Mark Bower, Paul J. Farrell, Päivi M. Ojala, Niklas Feldhahn, Simon J. Boulton
Publication Date: 21 January, 2021
Article Pages: 1 Open access contents
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