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Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML
Toshihiko Oki, Francois Mercier, Hiroki Kato, Yookyung Jung, Thomas O. McDonald, Joel A. Spencer, Michael C. Mazzola, Nick van Gastel, Charles P. Lin, Franziska Michor, Toshio Kitamura, David T. Scadden
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Article Pages: 1 Open access contents
BRD4-mediated repression of p53 is a target for combination therapy in AML
Anne-Louise Latif, Ashley Newcombe, Sha Li, Kathryn Gilroy, Neil A. Robertson, Xue Lei, Helen J. S. Stewart, John Cole, Maria Terradas Terradas, Loveena Rishi, Lynn McGarry, Claire McKeeve, Claire Reid, William Clark, Joana Campos, Kristina Kirschner, Andrew Davis, Jonathan Lopez, Jun-ichi Sakamaki, Jennifer P. Morton, Kevin M. Ryan, Stephen W. G. Tait, Sheela A. Abraham, Tessa Holyoake, Brian Higgins, Xu Huang, Karen Blyth, Mhairi Copland, Timothy J. T. Chevassut, Karen Keeshan, Peter D. Adams
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Article Pages: 1 Open access contents
A modular and controllable T cell therapy platform for acute myeloid leukemia
Mohamed-Reda Benmebarek, Bruno L. Cadilha, Monika Herrmann, Stefanie Lesch, Saskia Schmitt, Stefan Stoiber, Abbass Darwich, Christian Augsberger, Bettina Brauchle, Lisa Rohrbacher, Arman Oner, Matthias Seifert, Melanie Schwerdtfeger, Adrian Gottschlich, Felicitas Rataj, Nadja C. Fenn, Christian Klein, Marion Subklewe, Stefan Endres, Karl-Peter Hopfner, Sebastian Kobold
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Article Pages: 14 Open access contents
A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis
Jonathan Bond, Aleksandra Krzywon, Ludovic Lhermitte, Christophe Roumier, Anne Roggy, Mohamed Belhocine, Alexander Abdulkader Kheirallah, Patrick Villarese, Guillaume Hypolite, Francine Garnache-Ottou, Sylvie Castaigne, Nicolas Boissel, Vahid Asnafi, Claude Preudhomme, Hervé Dombret, Elisa Laurenti, Elizabeth Macintyre
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Article Pages: 12 Open access contents
Contribution of CTCF binding to transcriptional activity at the <i>HOXA</i> locus in <i>NPM1</i>-mutant AML cells
Reza Ghasemi, Heidi Struthers, Elisabeth R. Wilson, David H. Spencer
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Article Pages: 12 Open access contents
Comprehensive diagnostics of acute myeloid leukemia by whole transcriptome RNA sequencing
Wibowo Arindrarto, Daniel M. Borràs, Ruben A. L. de Groen, Redmar R. van den Berg, Irene J. Locher, Saskia A. M. E. van Diessen, Rosalie van der Holst, Edith D. van der Meijden, M. Willy Honders, Rick H. de Leeuw, Wina Verlaat, Inge Jedema, Wilma G. M. Kroes, Jeroen Knijnenburg, Tom van Wezel, Joost S. P. Vermaat, Peter J. M. Valk, Bart Janssen, Peter de Knijff, Cornelis A. M. van Bergen, Erik B. van den Akker, Peter A. C. ’t Hoen, Szymon M. Kiełbasa, Jeroen F. J. Laros, Marieke Griffioen, Hendrik Veelken
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Article Pages: 14 Open access contents
<i>getITD</i> for <i>FLT3</i>-ITD-based MRD monitoring in AML
Tamara J. Blätte, Laura K. Schmalbrock, Sabrina Skambraks, Susanne Lux, Sibylle Cocciardi, Anna Dolnik, Hartmut Döhner, Konstanze Döhner, Lars Bullinger
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Article Pages: 4 Open access contents