In Table 2, the coefficients of the prediction model are incorrect for rows 3–5 of the clinical factors/environmental predictor variables, and for some of the coefficients of model B). The correct table is below.
| Model A | Model B | Model C | Model D | |||||
|---|---|---|---|---|---|---|---|---|
| Coefficient | (95%CI) | Coefficient | (95%CI) | Coefficient | (95%CI) | Coefficient | (95%CI) | |
| Clinical factors/ Environmental predictor variables | ||||||||
| Male sex | 0.70 | (0.43;0.96) | 0.64 | (0.38;0.90) | 0.63 | (0.38;0.89) | 0.68 | (0.42;0.93) |
| Type of 1st VT (DVT, PE, PE+DVT) PE PE+DVT | -0.50 0.28 | (-0.76;-0.24) (0.02;0.55) | -0.50 0.30 | (-0.76;-0.25) (0.04;0.57) | -0.61 0.32 | (-0.87;-0.36) (0.06;0.58) | -0.69 0.31 | (-0.95;-0.44) (0.04;0.57) |
| Location of DVT (PE, distal DVT, proximal DVT) Popliteal§ and distal VT Proximal DVT | -0.40 0 | (-0.63;-0.17) omitted | -0.39 0 | (-0.63;-0.16) omitted | -0.46 0 | (-0.69;-0.23) omitted | -0.49 0 | (-0.72;-0.25) omitted |
| Surgery | -0.42 | (-0.78;-0.05) | -0.40 | (-0.76;-0.03) | -0.51 | (-0.88;-0.15) | -0.52 | (-0.88;-0.16) |
| Pregnancy/ puerperium | -1.31 | (-2.3;-0.30) | -1.34 | (-2.36;-0.33) | -1.49 | (-2.50;-0.48) | -1.44 | (-2.45;-0.43) |
| Hormone use | -0.59 | (-0.92;-0.26) | -0.51 | (-0.83;-0.18) | -0.67 | (-0.99;-0.35) | -0.62 | (-0.95;-0.30) |
| Plaster cast | -0.73 | (-1.31;-0.15) | -0.70 | (-1.28;-0.12) | -0.79 | (-1.37;-0.22) | -0.83 | (-1.40;-0.25) |
| Immobility in bed, in hospital | -0.30 | (-0.66;0.06) | -0.32 | (-0.68;-0.03) | -0.31 | (-0.67;-0.05) | -0.34 | (-0.69;0.02) |
| History of cardiovascular disease | -0.43 | (-0.86;0.01) | -0.44 | (-0.87;-0.01) | -0.36 | (-0.79;0.07) | -0.37 | (-0.80;0.06) |
| Genetic factors/ Genetic predictor variables | ||||||||
| Blood group, non-O versus O | 0.24 | (0.03;0.45) | ||||||
| Factor V Leiden mutation | 0.38 | (0.16–0.60) | 0.40 | (0.19;0.61) | ||||
| Laboratory factors/ Hemorheologic and coagulation predictor variables per unit increase | ||||||||
| lnDdimer (ng/mL)* | 0.26 | (0.05;0.47) | 0.24 | (0.04;0.44) | ||||
| lnFactor VIII antigen (IU/dL)* | 0.47 | (-0.11;1.05) | 0.81 | (0.43;1.19) | ||||
| Von Willebrand factor (IU/dL) | 0.39 | (-0.15;0.93) | ||||||
| lnCRP* | -0.09 | (-0.19;0.00) | ||||||
| Factor V (IU/dL) | 0.50 | (-0.16;1.17) | ||||||
| Factor X (IU/dL) | 0.01 | (0.00;0.02) | ||||||
| Fibrinogen (g/L) | -0.24 | (-0.42;0.05) | ||||||
| lnAPC ratio* | 0.25 | (0.10;0.40) | ||||||
Model A denotes the maximum model (i.e., all candidate predictor variables); model B, clinical variables and some laboratory markers easy to assess in the clinic; model C, clinical and genetic variables only; model D, clinical variables only. Variables presented in the table were included by a backward selection procedure (entry p < 0.15).
*A log-transformation was decided after a nonnormal distribution was found visually.
§ Indicates DVT at the level of the vena poplitea or below.
Abbreviations: APC, activated protein C; CRP, C-reactive protein; DVT, deep vein thrombosis; PE, pulmonary embolism
1
Correction: Prediction of recurrent venous thrombosis in all patients with a first venous thrombotic event: The Leiden Thrombosis Recurrence Risk Prediction model (L-TRRiP)
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